200455. lajstromszámú szabadalom • Eljárás pirimidin-származékok előállítására
17 HU 200455 B 18 X Y Z Q MMR{300 MHz, ppm) CHs-H H N02-(CDCb) 8.92 (dd, J = 4.2 Hz, 1H), 8.86 (d, J = 7 Hz, 1H), 8.52 (s, 2H), 8.42 (d, J = 7 Hz, 1H), 7.6 (dd, J = = 7.4 Hz, 1H), 7.06 (d, J = 7 Hz, 1H), 2.3 (s, 3H). CH3OCHs-H H (CDCU) 8.84 (dd, J = 4.2 Hz, 1H), 8.42 (dd, J = 7.2 Hz, 1H), 8.19 (s, 1H), 8.15 (dd, J = 8.1 Hz, 1H), 7.91 (dd, J = 8.1 Hz, 1H), 7.71 (t, J = 8 Hz, 1H), 7.4 (dd, J = 7.4 Hz, 1H), 3.72 (s, 3H), 2.02 (s, 3H). 0 II CHsCNHH H H (DMSO-ds) 8.88 (d, J = 7 Hz, 2H), 8.76 (m, 1H), 8.64 (d, J = 7 Hz, 1H), 8.2 (m, 2H), 7.6 (m, 2H), 2.16 (s, 3H). H H H F (DMSO-ds) 8.8 (m, 2H), 8.5 (d, J = = 7 Hz, 1H), 8.2 (m, 1H), 7.72 (m, 2H), 7.64 (dd, J = 7.4 Hz, 1H), 7.54 (t, J = 7 Hz, 1H). NH2-H H H (DMSO-ds) 8.86 (d, J = 7 Hz, 2H), 8.7 (m, 1H), 8.6 (d, J = 7 Hz, 1H), 7.8 • (d, J = 7 Hz, 1H), 7.54 (t, J = 7 Hz, 1H), 7.42 (dd, J = 7.4 Hz, 1H), 6.84 (d, J = 7 Hz, 1H), 6.72 (s, 1H). H H H (CHshN(DMSO-ds) 8.79 (d, J = 7 Hz, 2H), 8.5 (d, J = 5' Hz, 1H), 8.44 (dd, J = 7.1 Hz, 1H), 8.0 (d, J = = 7 Hz, 1H), 7.5 (t, J = 7 Hz, 1H), 7.42 (dd, J = 7.4 Hz, 1H), 7.26 (d, J = 7 Hz; 1H), 2.9 (s, 6H). CH3-H H NHz(DMSO-ds) 8.76-8.66 (m, 1H), 8.66- -8.54 tm, 2H), 7.75 (d, J = 8 Hz, 1H), 7.49-7.34 (m, 2H), 6.81 (d, J = 8 Hz, 1H), 6.73 (s, 2H), 2.49 (s, 3H). 0 l| CHs-H H CH3CNH-(DMSO-ds) 10.27 (s, 1H), 8.77 (dd, J = 4, 1 Hz, 1H), 8.64 (d, J = 9 Hz, 1H), 8.63 (d, J = 5 Hz, III), 8.17 (d, J = 4 Hz, 2H), 7.61 (dd, J = 9.4 Hz, 1H), 7.44 (d, J = 5 Hz, 1H), 2.48 (s, 3H), 2.24 (s, 3H). CHs-H H Cl (CDCI3) 8.84 (d, J = 3.7 Hz, 1H), (maleát só) 8.6-8.65 (m, 2H), 8.22 (d , J = 8.2 Hz, 1H), 8.1 (d, J = 8.0 Hz, 1H), 7.72 (dd, J = 8.6, 4.3 Hz, 1H), 7.44 (d, J = 5.3 Hz, 1H), 6.18 (s, 3H). (s, 2H), 2.46 C H 3— H CH3-Cl (CDCI3) 8.89 (dd, J = 4.3, 1.6 Hz, (maleát só) 1H), 8.55 (dd, J = 8.5, 1.6 Hz, 1H), 8.36 (d, J = 7.9 Hz, 1H), 7.82 (d, J = 8.5 Hz, 1H), 7.52 (dd, J = 8.4, 4.3 Hz, 1H), 6.92 (s, 2H), 2.41 (s, 6H). 1H), 6.35 (s, 11
