200455. lajstromszámú szabadalom • Eljárás pirimidin-származékok előállítására

19

HU 200455 B

20

X Y Z Q MMR(300 MHz, ppm)

CH30-H

CH3-H

(CDCh) 8.87 (dd, v

I = 4.3,

1.6

Hz,

1H), 8.43 (dd,

J =

7.2, 1.3

Hz,

1H),

8.18 (dd, J =

8.4,

1.9 Hz,

1H),

7.93

(dd, J = 8.3,

1.3

Hz, 1H),

7.73

(t,

J = 7.8 Hz, 1H), 7,42 (dd,

J =

8,4,

• 4.3 Hz, 1H),

6.4 (

is, 1H),

3.58

(s,

3H), 2.42 (s, 3H)

Í-C3

H70-H

HH

(CDCb) 8.87 (dd, v

I = 4.3,

1.7

Hz,

1H), 8.43 (dd,

J =

7.3, 1.4

Hz,

1H),

8.4 (d, J = 6.0 Hz, 1H),

8.19

(dd,

J = 8.5, 1.5 Hz, 1H), 7.93

(dd,

J =

= 8.4 Hz, 1H),

7.74

(t, J

= 7.4

Hz,

1H), 7.43 (dd,

J =

8.6, 4.3

Hz,

1H),

4.99 (Sep, J =

6.0

Hz, 1H),

1.01

(d,

J = 6.1 Hz, 3H), .98 (d, J

= 6.1

Hz,

3H).

{iCHzNHH

H

H

(DMSO-d6) 8.80

(bd,

J = 4.3

í Hz,

1H),

8.47 (dd, J =

8.5,

1.5 Hz,

1H),

8.21

(d, J = 5.6 Hz, 1H), 8.19

(dd,

J =

= 8.3, 1.5 Hz

, 1H), 8.05

(d, .

J == 8.2 Hz, 1H),

7.87

(t, J ■

= 8.0

Hz,

1H), 7.59 (dd,

J =

8.4, 4.2

Hz,

1H),

7.18 (bs, 3H),

6.88 (bs,

2H),

6.45

(d, J = 5.7 Hz, 1H]

1, 4.13 (b AB

quart., 2H).

^N(CH3)H

H

H

(DMSO-d6) 8.84

(dd,

J = 4.0, 1.4

Hz,

1H), 8.49 (dd,

J =

8.4, 1.5

Hz,

1H),

8.21 (d, J = 5.9 Hz,

1H), 8.18 (t,

J =

= 3.9 Hz, 1H),

8.08

(d, J

= 6.4

Hz,

1H), 7.87 (t, .

J =

7.8 Hz,

1H),

7.60

(dd, J = 8.4,

4.1

Hz, 1H),

7.42--7.28

(m, 3H), 7.18

(d, .

J = 7.7

Hz,

2H),

6.28 (d, J = 5.

9 Hz,

1H), 3.08 (s,

3H).

0CH2N(C1Í3)H

H

H

(DMSO-dc) 8.75

(bs,

1H), 8.40

(bd,

J =

= 8.2 Hz, 1H),

8.18

(d, J

= 5.7

Hz,

1H), 8.08 (bd,

J =

8.1 Hz,

1H),

7.79

(bt, J = 8.2 Hz, 1H), 7.50

(dd,

J =

= 8.3, 4.2 Hz

, 1H)

1, 7.00-7.24 (vbm,

3H), 6.50-6.80

(vbm,

3H), 4

.52 (vbd,

J = 10.7 Hz, 1H), 4.22 (vbs,

1H),

2.81

(s, 3H).

H

Cl

H

H

(DMSO-d6) 8.75

(dd,

J = 4, :

Z Hz,

1H),

8.47 (dd, J =

8, 2

Hz, 1H),

, 8.25

(d,

J = 7 Hz, 1H),

8.22

(d, J =

7 Hz,

1H),

7.89 (t, J = 8

Hz,

1H), 7.83 (s,

2H),

7.44 (dd, J

=

4, 2

Hz,

1H).

H

Br

H

H

(DMSO-d6) 8.74

(dd,

J = 4, :

1 Hz,

1H),

8.47 (dd, J =

8, 2

Hz, 1H),

, 8.24

(d,

J = 7 Hz, 1H),

8.20

(d, J = '

7 Hz,

1H),

7.89 (t, J = 8

Hz,

1H), 7.83

1 (s,

2H),

7.56 (dd, J

=

4, 2

Hz,

1H).

12