200455. lajstromszámú szabadalom • Eljárás pirimidin-származékok előállítására

15

HU 200455 B

16

X

Y

Q

MMR(300 MHz, ppm)

C2H5OH

(CH3)zNCII3-C2H3-H

CH3-H CH3- H (CDCh) 8.86 (dd, J = 4.2, 1.9 Hz, 1H),

8.42 (d, J = 7.3 Hz, III), 8.18 (bd, J =

= 8.2 Hz, 1H), 7.92 (d, J = 7.7 Hz, 1H), 7.73 (t, J = 7.8 Hz, 1H), 7.42 (dd,

J = 8.2, 4.1 Hz, 1H), 6.37 (s, 1H),

4.0 (bq, J = 7.0 Hz, 2H), 2.43 (s, 3H), .97 (t, J = 7.1 Hz, 3H).

H H H (CDCls) 8.85 (dd, J = 4.3, 1.7 Hz, 1H),

8.43 (m, 2H), 8.19 (dd, J = 8.2, 1.7 Hz,

1H), 7.94 (bd, J = 7.2 Hz, 1H), 7.75

(t, J = 7.1 Hz, 1H), 7.43 (dd, J = 8.2,

4.3 Hz, 1H), 6.51 (d, J = 6.2 Hz, 1H),

4.63 (bq, 1H), 1.35-1.6 (m, 7H), 1.08-.-1.2+ (m, 3H).

H

H

Cl

(CDCh) 8.88

(dd, J = 4.3

, 1.7

Hz,

1H),

8.73,

(dd

, J

= 5.0, 1.3

Hz,

2H),

8.57

(dd,

J =

8.3,

1.2 Hz, 1H)

, 8.4

(d,

J =

= 7.9 Hz,

1H)

, 7.85 (d, J

= 7.9 Hz,

1H),

7.53

(dd,

J

= 8.4, 4.2

Hz,

1H),

7.25

(t, J

= 5.0 Hz

, 1H).

H

CH3-H

(CDCh) 8.91

(dd, J = 4.3

, 1.6

Hz,

1H),

8.42

(dd,

J

= 7.6, 1.6

Hz,

1H),

8.16

(dd,

J =

8.4, 1.9 Hz, 1H),

7.88

(dd,

J =

8.4,

1.3

Hz, 1H), 7.7

(t, J

= 7.8

Hz,

1H),

7.4 1

(dd,

J = 8.1, 4.3

Hz,

1H),

5.92

(s,

1H),

3.12

(bs, 4H),

2.33

(s,

3H),

1.71--1.87

(bm,

4H).

H

CH3-H

(CDCh) 8.9 (dd, J = 4.3,

1.9

Hz,

1H),

8.42

(dd,

J

= 7.5, 1.8

Hz,

1H),

8.16

(dd,

J =

8.7, 1.9 Hz, 1H),

7.89

(dd,

J =

8.3,

1.4

Hz, III), 7.7

(t, J

= 7.6

Hz,

1H),

7.4 1

(dd,

J = 8.2, 4.3

Hz,

1H),

6.06

(s,

1H),

2.77

(bs, 6H),

2.35

(s,

3H).

H

H

H

(CDCh) 8.86

(dd, J = 4.3

, 1.6

Hz,

1H),

8.5

(d,

J

= 4.8 Hz, 1H),

8.46

(dd,

J =

7.2

’, 1.3 Hz, 1H),

8.17

(dd,

J =

8.8,

1.6

Hz, 1H), 7.93 (dd, J=

8.3,

1.3 1

Hz, 1H),

7.75 (t, J =

7.8

Hz,

1H),

7.41

(dd,

J =

8.2, 4.3 Hz,

1H),

, 7.06

(d,

J =

4.!

9 Hz, 1H), 2.51

(s,

3H).

H

CH3-H

(DMSO-de)

8.76 (dd, J =

4.0,

1 1.4

Hz,

1H),

8.47

(dd, J = 8.5,

1.5

Hz,

1H>,

8.22

(dd,

J

= 7.3, 1.4

Hz,

1H),

8.18

(dd,

J =

7.9,

, 1.2 Hz, 1H), 7.88 (t.

, J=

= 7.

8 Hz, 1H), 7.56 (dd, .

J =

8.1,

4.2

Hz,

1H),

7.28 (s, :

LH),

2.56

(qi

J =

7.5

Hz,

211), 2.36

(s,

3 H),

.91

(t, J

= 7.6 Hz,

3H).

11

H

NO2-(DMSO-de)

8.84 (in, 4H),

8.74

(d,

J =

= 7

Hz,

1H),

8.42 (d, J

= 7

Hz,

1H),

7.8

(dd,

J

= 7.4 Hz,

1H),

7.6

(t,

J = 8 Hz,

1H).

H

CH3

NO2-(DMSO-de)

8.82 (in, 2H),

8.64

(d,

J =

= 7

Hz,

1H),

8.34 (d, J

= 7

Hz,

III) je

7.78

(dd,

J

= 7.4 Hz,

1H),

7.28

(s,

1H), 2.3 (s, 6H).

10