200455. lajstromszámú szabadalom • Eljárás pirimidin-származékok előállítására

13

HU 200455 B

14

X Y Z Q MMR(300 MHz, ppm)

= 8.4, 7.3 Hz, 1H), 7.59 (dd, J = 8.1,

4.3 Hz, 1H), 7.3 (bs, 2H), 6.35 (d, J =

. = 6.0 Hz, 1H).

CH3- H CH3 H (CDCb) 8.87 (dd, J = 4.3, 1.9 Hz, 1H),

8.44 (dd, J = 7.2, 1.9 Hz, 1H), 8.16

(dd, J = 8.2, 1.6 Hz, 1H), 7.91 (dd, J =

= 8.0, 1.6 Hz, 1H), 7.73 (t, J = 7.8 Hz, 1H), 7.41 (dd, J = 8.1, 4.3 Hz, 111),

6.9 (s, 1H), 2.40 (s, 6H).

j H H H (CDCb) 8.78 (dd, J = 4.3, 1.6 Hz, 1H),

8.70 (dd, J = 7.2, 1.3 Hz, 1H), 8.16

(dd, J = 8.2, 1.7 Hz, 1H), 8.07 (dd,‘

J = 7.9, 1.0 Hz, 1H), 8.04 (d, J = 5.8 Hz, 1H), 7.71 (dd, J = 8.3, 7.1 Hz, 1H),

7.37 (dd, J = 8.2, 4.3 Hz, 1H), 6.21 (d, J = 5.8 Hz, 1H), 3.4 (bt, J = 5.9 Hz, 2H), 3.27 (bt, J = 5.7 Hz, 2H), 1.99

(bq, J =6.1 Hz, 2H), 1.84 (bq, J = = 6.0 Hz, 2H).

(CzHsízNH

cTAc- \_/

H

(n-C3H7)2NH

H H (CDCb) 8.9 (dd, J = 4.1, 1.9 Hz, 1H),

8.42 (dd, J = 7.3, 1.3 Hz, 1H), 8.10--8.19 (m, 2H), 7.9 (dd, J = 8.3, 1.3 Hz, 1H), 7.72 (t, J = 7.8 Hz, 1H), 7.42

(dd, J = 8.5, 1.0 Hz, 1H), 6.18 (d, J = 5.7 Hz, 1H), 3.19 (bq, J = 7.2 Hz, 4H), .65-.98 (bm, 6H).

(DMSO-de)

8.82

(dd,

J =

4.4

, 1.9

Hz,

1H),

8.47

(dd,

J =

8.7,

1.7

Hz,

1H),

8.19

(dd,

J =

6.9,

1.6

Hz,

1H),

8.14

(d, J

6.4 Hz, 1H), 7.86

(dd,

J =

= 8.6,

, 6.9

Hz,

1H),

7.58

(dd,

J =

8.1,

4.3 Hz, 1H), 6.77 (d, J = 6.3 Hz, 1H), 3.48 (m, 4H), 3.37 (m, 4H).

H H (CDCb) 8.91 (dd, J = 4.3, 1.6 Hz, 1H),

8.42

(dd,

J =

7.2,

1.3

Hz,

1H),

8.16

(dd,

J =

: 8.2,

1.7

Hz,

1H),

8.09

(d,

J =

6.3

Hz, 1H), 7.89

(dd,

J =

8.4,

1.5

Hz, 1H), 7.

70 (t,

, J

= 7.5

Hz,

1H),

7.41

(dd,

J =

8.5,

4.0

Hz,

1H),

6.26

(d,

J =

6.4 Hz, 1H),

3.37

(bt,

J =

= 5.3 Hz,

4H),

1.55

(bq, J =

= 5.6

Hz,

2H),

1.38

(bs, 4H).

(CDCb) 8.87 (dd, J

= 4.

2, 1.2

Hz,

1H),

8.42

(dd,

J =

7.2,

1.6

Hz,

1H),

8.16

(m,

2H),

7.91

(dd,

J :

= 7.8,

1.0

Hz,

1H),

7.72

(t,

J =

7.8

Hz,

1H),

7.2

(dd,

J =

8.2,

4.3

Hz,

1H),

6.18

(d,

J =

6.3

Hz,

1H),

3.08

(bsext.,

4H),

1.84

(bs,

2H)

, 1.46

(bs,

2H),

.84

(bs, 3H), .50 (bs, 3H).

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