191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

191 378

II. táblázat folytatása

Vegyület

száma

u

V

w

X

y

z IR

NMR

2-15

H

H

H

Cl

Na

—STetCH, CH2 KBr: 1

D20:

N(CH3)2 3420, 1765, 1685

2,31 (s, 6H), 3,00(t,2H,J=6), 3,52 (s, 311), 3,60 (s, 2H),

4,20 (s, 2H), 4,54 (t, 2H, J = 6), 4,67 (bs, 2H), 5,16 (s, 1H),

6,28 (d, 1H, J = 6), 6,57 (d, 1H, J = 6)

2-16

H

H

H

Cl

H

-STetCH:CH2NH

1

IIOjS KBr:

3400,1780, 1225,1040

2-17

11

11

II

Cl

II

STelCII; CIIjOH

Nujol: 3380,3250, 1770,1700, 1650,1630 op.: 99 °C

DMSO-d6:

3,40 (s, 3H), 3,53 (s,2H),4,43 (t.2H,J = 5), 4,03-4,93 (m, 8H), 5,08 (s, 1H), 6,35 (d, 1H, J =6), 6,77 (d, 1H, J = 6), 9,13 (m, 1H)

2-18

H

H

II

Cl

H- STetCH2CH2 OC'H3

TLC (etilacetát: H2 0:AcOH = 8:1:1):

Rf = 0,54

2-19

H

H

H

Cl

H

-STetCH2CH20

1

Aceton-d6:

1

CIIIjCCO

KBr:

3400.3270 1780,1753, 1721,1655

3,49 (s,3H), 3,57 (s, 2H), 4,21 (s, 2H), 4,34 (s, 2H), 4,66 (s, 6H), 5,09 is, 1H), 6,23 (d, 1H, J = 7), 6,72 (d, 1H,J = 7)

2-20

H

H

H

Cl

H

~STetCHzCHOH

1

Aceton-d6:

2-21

H

H

H

Cl

H

ch2 oh

Nujol: 3270,1770, 1700,1640

—STetCH2CONII2

3,48 (s,3H), 3,58 (s, 2H),4,33 (bs, 2H), 4,63 (bs,2H), 3,50- 4,67 (m,8H), 3,5,08 (s, 1H), 6,23 (d, 1H, J = 6), 6,75 (d, 1H, J = 6), 8,03-8,32 (m, 1H) Aceton-d6-CD3 OD(=l :1):

Nujol:

3326, 3200, 3,50 (s, 3H), 3,60 (s, 2H), 4,30

2723, 1780, (s, 2H), 4,62 (s,2H), 5,12 (s,

1688, 1635 1H). 5,18 (s, 2H), 6,27 (d, 1H,

J = 6), 6,73 (d, 1H, J = 6)

15