191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

191 378

II. táblázat folytatása

Vegyület

száma

u

V

w

x y

7 IR

NMR

2-22

H

H

H

Cl H

1.3,4-tiadiarol-2-il-tio

TLC(etilacetát:H20:AcOH = 16:1:1)

Rf = 0,38

2-23

H

11

H-SCIIj 11

~STctCH3 Niijol:

1780,1710, 1680

Acetor.-d6:

2,30 (s,3H), 3,48 (s,5H),3,98 (s, 3H), 4,32 (s, 2H), 4,65 (s, 2H), 5,08 (s, 1H), 5,73-6,33 (m, 2H), 6,20 (s, 2H)

2-24

11

11

CN

Cl 11

S lctCII3

Aceton-d6:

3,50 (s, 311), 3,92 (s, 2H), 3,98 (s, 3H), 4,37 (s, 2H), 4,70 (s, 2H), 5,15 (s, 1H), 8,03 (s, 1H)

2-25

H

H-ch2

1

Cl H-STetCH3 Nujoí:

D20:

OH

3250. 1770, 1670, 1620

3,97 (s,3H), 4,07 (s, 2H), 4,50 (s,3H), 4,63 (bs,5H), 5.00 (s, 2H),5,62, (s, 1H), 7,05 (s, 1H)

2-26

H

H-co

1

CI II-STetCII3 Nujol:

Aceton-d6:

nh2

3150,1770, 1655

3,50 (s,3H), 3,83 (s, 2H), 4,00 (s, 3H), 4,36 (s, 2H), 4,67 (s, 2H), 5,10 (s, 1H), 6,96 (bs, 2H), 7,98 (s, 1H), 8,37 (bs, 1H)

2-27

H

H-COOH

Ci H- STetCI I3 KBr:

3420,1780, 1705

Aceton-d6:

3,50 (s, 311), 3,80 (s, 2H), 4,02 (s,3H), 4,35 (s, 2H), 4,68 (s, 2H), 5,13 (s, 1H), 8,15 (s, 1H)

2-28

H

H

Cl

Cl H-STetCH3 Niijol:

3200,1770, 1710,1665, 1625

Aceton-d6:

3,50 (s,3H), 3,65 (s, 2H), 4,00 (s, 3H), 4,35 (s, 2H), 4,68 (s, 2H), 5,12 (s, 1H), 6,85 (s, 1H), 6,58-7,08 (m, 1H)

2-29

H

~(CH2)3CO

Cl II

STetCH3 Nujol:

1782.1710, 1678

DMSO-d6:

1,85-2,83 (m,6H), 3,40 (s, 3H), 3,91 (s, 3H), 4,21 (s, 2H), 4,55 (s. 2H), 5,10 (s, Ifi), 7,10 (br, 1H)

2-30

H-CN-CN-SCH3 h-STetCHj KBr:

3460,3380, 3300,2310, 1785,1705, 1623,1597

Aceton-d6:

6,60 (s, 2H), 5,13 (s, 1H), 4,70 (s, 2H), 4,37 (s, 2H), 4,18 (s, 211), 4,00 (s,3H), 3,55 (s, 3H), 2,77 (s, 3H)

16