185956. lajstromszámú szabadalom • Eljárás új amidin-származékok és a vegyületeket tartalmazó gyógyászati készítmények előállítására

185 956

5. táblázat folytatása

Op. CC)

IR v*?xrcm-' max

NMR (DMSO-d6) 5

4-NH-C<TM

H

4_NH_C<JTM

H

28

4—N—C<^{Jl“CH3

H

29

4—S02NH2

H

30

4—SCH3

H

(114) képletü

csoport

2HC1

2MSA

MSA

MSA

170-178 3400-2510, 1725, 1240

223-229 3320, 3120, 1705, 1660, 1183

270-279 3600-2900, 1720, 1663, 1201

43-46 3300, 3100, 1730, 1670, 1200

217-220 3350, 3150, 1730, 1675

243-245 3320, 3110, 1722, 1676, 1250, 1200

264-266 3400-2900, 1720, 1700, 1650

243-245 3150, 1730, 1660

240-242 3400, 3340, 3100, 1729, 1680, 1205

260-263 3330, 3100, 1725, 1668

1.87 (3H, S), 3.02 (6H, S), 7.00-9.40 (m)

2.47 (3H, S), 3.01 (6H, S), 6.73-8.63 (10H, m), 9.00-9.60 (4H, b)

2.6 (6H, S), 7.50-8.70 (l4H, m), 9.20-9.83 (4H, b), 10.23 (1H, S)

2.30 (6H, S), 6.70-8.73 (22H, m), 8.97-9,73 (44,b), 10.58 (1H, S)

7.5 (d7>), 7.7-8.8 (m), 9.6 (b), 9.8 (b), 10.9 (b)

2.48 (6H, S), 3.42 (3H, S), 7.17-8.67 (14H, m), 9.10-9.67 (4H, m)

2.20 (3H, S), 7.77-8.68 (10H, m),

10.03-10.53 (4H, b)

2.50 (3H, S), 2.57 (3H, S), 7.37-8.60 (10H, m), 9.10-9.70 (4H, b)

31

4—CHO

H

MSA

32

4—OCCH3

H

MSA

33

3-CF3

H

MSA

34

4—N02

3-CH3 -MSA

35

4—NH2

3-CH3 -2MSA

36

4-NH-C<TM

3-CH3 -2MSA

37

4—N02

2-C1

MSA

38

4—NH2

2-C1

2MSA

39

4-NH-C<TM

2-C1

2MSA

144-147 3250, 3100, 1750, 1730 (Sh), 1500, 1320

162-165 3350, 3100, 1745, 1675, 1200

68-71 3300, 3150, 1740, 1670, 1520, 1200

120-123 3300, 3150, 1740 (Sh) 1670, 1200

164-170 3550-2900, 1745, 1660, 1210, 1150, 700

158-160 3250, 3080, 1755, 1680, 1342

153-155 3255, 3150, 1755, 1680, 1660 229-232 3350, 3150, 1730, 1680 176-181 3350, 3150, 1720, 1675, 1625, 1230

50 4—OOCCH3 H

51 4—NH2 H

2.30 (3H, S), 2.50 (3H, S), 3,07 (4H, S), 7.23-8.36 (10H, m), 8.86-9.63 (4H, m)

2.27 (3H, S), 2.90 (4H, S), 6.60—8.63 (16H, m),

9.06-9.89 (4H, b)

2.53 (6H, S), 3.06 (4H, S), 7.17-8.64 (14H, m), 9.17-9.70 (4H, b), 9.87 (1H, S)

1.30 (3H, t8>), 2.40-2.83 (8H, b), 3.77 (2H, m), 7.33-8.70 (20H, m), 9.20-9.83 (4H, b),

10.16 (1H, S)

1.73-2.47 (2H, m), 2.70 (3H, S), 2.50-3.07 (2H, m), 7.08-8.57, (11H, m), 8.67-9.57 (4H, b)

1.87-3.10 (6H, m), 2.47 (3H, S), 7.33-8.67 (10H, m), 9.00-9.67 (4H, b)

2.40 (3H, S), 2.43 (3H, S), 7.03-8.90 (12H, m), 9.37-10.04 (4H, b)

—CH2CH2 MSA

—CH2CH2— (114) képletű

csoport

15