185956. lajstromszámú szabadalom • Eljárás új amidin-származékok és a vegyületeket tartalmazó gyógyászati készítmények előállítására

185 956

Op. ce)

52

53

54

55

56

57

58

179-181

167-169

195-197

161-162

214-218

162-164

247-249

148-150

180-183

129-134

182-185

213-217

172-175

235-238

(bomlik)-117

(bomlik)-175

(bomlik)

239-242

(bomlik)

126-128

200-210

40

41

42

43

44

45

46

47

IR Vm?*rCm'' max

.5. táblázat folytatása

NMR (DMSO-d6) 5

4-NH-C<ÍS2

H

4-NH-CCTM

H

H

H

4—N02

H

4—NHOCCHj

H

H

H

4 CH3

H

—CH2CH2

2MSA

—ch2ch—

2MSA

ch2ch3

—ch2ch2ch2—

MSA

—ch2ch2ch2—

MSA

—ch2ch2ch2—

MSA

—CH=CH—

MSA

—CH=CH—

MSA

3550-3050, 1750, 1660, 1215, 1135, 710, 550, 530

3450-2900, 1750, 1670, 1202 3400-2750, 1748, 1670, 1200 3330, 3100, 1760, 1670

3300, 3100, 1740, 1670, 1340

3300, 3150, 1745, 1670, 1187 3400-3000, 2900, 1745, 1670, 1200, 1135, 690, 540, 520

3300, 3100, 1750, 1670, 1200

3350, 3150, 1750, 1680, 1225 3300, 3100, 1745, 1670, 1630

3350, 3150, 1720, 1670, 1200

3300, 3100, 1730, 1670, 1195

3320, 3150, 1733, 1685, 1230 3330, 3120, 1730, 1680, 1520, 1350

3300, 3100, 1725, 1670

3300, 3150, 1720, 1600

3400-3000, 1730, 1670, 1520, 1210

3550-2800, 1730, 1660, 1200, 1140, 1090, 1035, 775, 550

3450-2950, 1730 (Sh), 1670, 1200, 1040, 775, 550, 530

H

H

H

H

4—CH2CHCH3

H

ch3

3—OCH3

H

4—Cl

H

4—Cl

H

H

H

H

H

2.50 (3H, S), 4.07 (2H, S), 7.20-8.83 (12H, m), 9.10-9.78 (4H, b)

2.47 (3H, S), 3.78 (3H, S), 4.05 (2H, S), 6.73-8.67 (10H, m), 9,13-9.67 (4H, b)

2.50 (3H, S), 4.10 (2H, S), 7.50-8.60 (10H, m), 9.17-9.70 (4H, b)

0.67-2.43 (10H, m), 2.52 (3H, S), 3.43-3.97 (2H, m), 7.20-8.77 (11H, m), 9.18-9.93 (4H,

b)

2.57 (3H, S), 3.07 (4H, S), 7.37 (5H, S), 7.57-8.74 (6H, m), 9.34-10.07 (4H, b)

2.47 (3H, S), 2.93 (4H, S), 3.73 (6H, S), 6.86-8.59 (9H, m), 9.09-9.76 (4H, b)

2.47 (3H, S), 7.63-8.70 (10H, m), 9.26-9.89 (4H, b), 10.23 (1H, S)

2.50 (3H, S), 2.67 (3H, S), 7.50-8.70 (10H, m), 9.17-9.67 (4H, b)

2.48 (3H, S), 2.62 (3H, S), 7.62-8.78 (9H, m), 9.18-9.75 (4H, b)

2.28 (3H, S), 2.57 (6H, 8), 7.55-8.85 (12H, m), 9.22-9.85 (4H, b)

2.40 (3H, S), 2.48 (6H, 8), 7.37-8.70 (13H, m), 9.20-9.63 (4H, b), 9.78 (1H, b)

2.50 (3H, S), 7.57-8.83 (9H, m), 9.13-9.80 (4H, b)

2.57 (3H, S), 7.50-8.82 (13H, m), 9.15-9.82 (4H, b), 10,45 (1H, S)

—ch2

MSA

ch3

MSA

1

— CH —

ch3

MSA

1

—CH—

—ch2—

MSA

ch2

MSA

ch3

MSA

— CH—

(115) képletű csoport

MSA

—CH2CH2—

MSA

16