185850. lajstromszámú szabadalom • Eljárás 7-[(tiazol-4-il)-acetamido-,ill hidroxi-imino-v alkoxi-imino acetamidól]-delta-3-cefém-4-karbonsav-származékok előállítására

J 85 850

27. táblázat (folyt.)

R1

Op.

(°C)

IR(KBr) cm-"'' : VC=0

NMR(dg-DHSO) ppm

*

~r

166-168 bora lile

1775, 1745 , 1665

2.41 (3H, s, >~CH,), 3.58 (2H, bs, C--H),

N — £ '

3.93 (3H, 5, -0CH3), 5.19 (1H, d, J=5Hz, Cg-H), 5.62 (2H, bs, S~] ), 5-78 (1H, dd, J=5Hz,

ch2-J=8Hz, C--H), 6.88 (1H, s, JT ), 7.62 (1H, s,

S ' H

7-67 - 8-°° (4h’ m» {0)). 9-8°

(1H, d, J=8Hz, -CONH-)-CH-OCCH..

2 II 3

0

121-124

bomlik

1780,

1745,

1670

2.10 (3H, s, -OCCH,), 2.46 (3H, s, N\ rH >.

il 3 -1

0

3.52 (2H, bs, C2-H), 3.82 (3H, s, -OCH3), 5.19 (1H, d, J=5Hz, C6-H), 5.59 (2H, bs, S'J ),

5.7Ő (1H, dd, J=5HZ, J=8Hz, C7-H), 5.83 (2H, s,-COOCHpO-), 6.69 (1H, s, T 7.12 (2H, bs,

S XH-NH2), 9.55 (1H, d, J=8Hz, -C0NH-)-CH20(CH2)3CH3

148-152

bomlik

1785,

1730,

1675

0.88 (3H, t, J=7Hz, -(CH2)3CH3), 1.05 - 1.75

N\

(4H, m, -CH2CH2CH2CH3), 2.45 (3H, s, ^-CH3),

3.45 (2H, t, J=7Hz, -CH2CH2CH2CH3), 3.55 (2H, bs, C2-H), 3.87 (3H, s, -OCH3), 5.23 (1H, d, J=5Hz, C6-H), 5.43 (2H, s, -COOCH20-), 5-62 (2H,

S-i

bs, ), 5.86 (1H, dd, J=5Hz, J=8Hz, C,-H),

'ch2- 7 6.74 (1H, s, ). 9.63 (1H, d, J=8Hz, -CONH-)-CHOCOCH-CH,

1 5 3

CH3

130-136

bomlik

1780,

1775,

1665

1.20 (3H, t, J=7Hz, -CH2CH3), 1.51 (3H, d,

N\

J=6Hz, PCH-CH3), 2.45 (3H, s, 3,55

(2H, bs, C2-H)3^85-43H'r-fr^rpCH,)? 4.16 (2H, q, J=7Hz, -CH2CH3), 5-20 (1H, d, J=5Hz, Cg~H),

5.55 (2H, bs, ^ ), 5.81 (1H, dd, J=5Hz,

^CHp— N—ti—

J=8Kz, C--H), 6.72 (1H, s, R ), 6.8l (1H, q,

' S H

J=6Hz, ^CH-CHg), 9.60 (1H, d, J-8Hz, -CONH-)