185850. lajstromszámú szabadalom • Eljárás 7-[(tiazol-4-il)-acetamido-,ill hidroxi-imino-v alkoxi-imino acetamidól]-delta-3-cefém-4-karbonsav-származékok előállítására

Í85 850

27. táblázat (folyt.)

R1

Op,

(°C)

IR(KBr) cm"^ : VC=0-CHOCC(CHj)-127-130

1780,

! 1! 33

1740,

1 0

bomlik.

1675

CH3

NMR(dg-DMSO) ppm

1.14 (9H, s, -C(C»3)3), 1.48 (3H, d, J=5.5Hz,

^TCH-CHj), 2.45 (3H, s, N\ch ), 3.48 (2H, bs,

tr -3.

C2-H), 3.32 (3H, s, -OCH3), 5.19 (1H, d, J=5Hz, Cfi-H), 5.54 ( 2H, bs, S3V ), 5.83 (1H, dd,

u ^ '/MI

ch2-N-n-J=5Hz, J=3fíz, C7-H), 6.69 (1H, s, A ),

' S

6.86 (III, q, J = 5.5»z, >CH-CH3), 7.11 (2H, bs, -NH2), 9.56 (1H, d, J=8Hz, -CONH-)-CHo0C(CH_)qCH3 2 N 2 3 3

107-108

1780,

1760,

1670

0.87 (3H, t, J=7Hz, -(CH2)3CH3), 1.0 - 1.7 (4h, m, -CH2CH2CH2CH3), 2.25 - 2.55 (2H, m,

N\-CH2CH2CH2CH3), 2.45 (3H, s, ^ACÍV* 3.33

(2H, bs, C2-H), 3.85 (3H, s, -0CH3), 5.20 (1H,

d, J=5Hz, Cfi-H), 5.58 (2H, bs, S~1 ), 5.88

(2H, s, -0CH20-), 5.73 - 5.97 (1H, m, C?-H),

6.70 (1H, s, X ), 7.18 (2H, bs, -NHp), 9.60 S XH

(1H, d, J=9Hz, -C0NH-)

CH0C0(CHo)-CHII 2 3 3

0

CH-.

I25-I3O

bomlik

1780,

I76O,

1667

0.87 Í3H, t, J=6Hz, -(CH2)3CH3), 1.15 - 1.70 (4M, m, -CH2CH2CH2CH3), 1.53 (3H, d, J=6Hz,

^CH-CH,), 2.46 (3H, s, «1 ), 3-54 (2H,-1 N

bs, C2-H:, 3.86 (3H, s, -0CH3), 4.11 (2H, t, J=6Hz, -CH2CH2CH2CH3), 5.23 (1H, d, J=5Hz,

C.-H), 5 59 (2H, bs, S^3 ), 5.85 (1H, dd,

D 'N pu _

ch2-NT

J=5Hz, J--8Hz, C7-H), 6.76 (1H, s, A ),

' S H

6.8I (1H, q, J=6Hz, 2?CH-CH3), 9.65 (1H, d,

J=8Hz, -C0NH-)

73