154813. lajstromszámú szabadalom • Eljárás egy terakozapeptid előállítására

B ábra. Prop-Tyr-Ser-Nle-Glu-His-Phe-Arg- Try-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro- Val-Lys-Val-Tyr-Pro-Val-NH2 előállítása CBOTyr —OH H—' Ser Nie — OMe CBO— Tyr Ser Nie —OMe Prop—OCP HTyr Ser Nie —OMe OTB Tri R R R R Prop-Tyr Ser Nie Prop— Tyr Ser Nie Prop— Tyr Ser Nie -OMe Tri— Glu His Ehe Arg Try Gly Lys Pro j— OH H—j Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Val -NH, OTB Tri R -NHNH, Tri—! Glu His Phe Arg Try Gly Lys Pro OTB Tri R HN3

H— Glu His Phe Arg Try Gly Lys Pro R R R Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Val -NH, R R R Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Val -NH, OTB Tri R R R R Prop— Tyr Ser Nie Glu His Phe Arg Try Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Val -NH2 Prop— Tyr Ser Nie Glu His Phe Arg Try Gly Lys Pro Val Gly Lys Lys Arg Arg Pro Val Lys Val Tyr Pro Val j—NH,