Antall József szerk.: Pictures from the Past of the Healing Arts / Orvostörténeti Közlemények – Supplementum 5. (Budapest, 1972)

Communicationes de História Artis Medicinae and Libri Históriáé Medicae

tablets and ampoules SPASMOLYTIC COMPOSITION:6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hyd­rochloride (Drotaverine hydrochloride) 40 mg per tablet and ampoule (2 ml) ACTIONS: Already in small doses, No-Spa relieves or prevents spastic conditions of the smooth muscles, irrespective of their localization, function or innervation. The spasmolytic effect of No-Spa is stronger than that either of papaverine or of Perparin (two drugs with similar action), and is accompanied by less of toxic side-effects. No-Spa is easily absorbed and exerts a prolonged action. The advantageous properties of the drug assert themselves particularly in the painful affections of the biliary, urogenital and gastrointestinal tract. INDICATIONS: In general, to abolish or prevent pain and dysfunction caused by smooth muscle spasm. Biliary and renal colics, spasms associated with cholecystopathy, cholelithiasis, chole­cystitis, nephrolithiasis, pyelitis, cystitis, as well as spasms elicited by instrumental examination. Spastic conditions of the gastrointestinal system; gastric and duodenal ulcer, larÿñgo-, cardio- and pylorospasm, spastic constipation, colitis, proctitis, tenes­mus. In acute blood-pressure fluctuations of hypertensives, administered in conjunction with antihypertensive drugs. Coronary and cerebral vascular spasm; intermittent clau­dication; dysmenorrhoea; to reduce the irritability of the pregnant uterus; in spasm of the uterinal orifice during delivery, protracted first stage of labour, after-pains, threat­ened abortion, etc.; in case of postoperative wind colics. DOSAGE: The average dose for adults is daily three times 1 to 2 tablets or daily once to three times 2 to 4 ml injected subcutaneously or intramuscularly. In emergency, e.g. acute stone colic, 2 to 4 ml may be given by slow intravenous injection. In case of peripheral arterial spasm or obstruction No-Spa may be injected intraarterially. Children should be given smaller doses according to age and body-weight. Small children should receive once or twice daily ¼ to ½ tablet, older children ½tol tablet daily. In peptic ulcer it is expedient to combine No-Spa with atropine or atropine-like com­pounds. PACKING: 20 tablets, 40 mg 100 tablets, 40 mg 1000 tablets, 40 mg 5 ampoules, 40 mg (2 ml) 50 ampoules, 40 mg (2 ml) CHINOIN Pharmaceutical and Chemical Works LTD Budapest — Hungary NO-SPA

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