Antall József szerk.: Pictures from the Past of the Healing Arts / Orvostörténeti Közlemények – Supplementum 5. (Budapest, 1972)
Communicationes de História Artis Medicinae and Libri Históriáé Medicae
tablets and ampoules SPASMOLYTIC COMPOSITION:6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride (Drotaverine hydrochloride) 40 mg per tablet and ampoule (2 ml) ACTIONS: Already in small doses, No-Spa relieves or prevents spastic conditions of the smooth muscles, irrespective of their localization, function or innervation. The spasmolytic effect of No-Spa is stronger than that either of papaverine or of Perparin (two drugs with similar action), and is accompanied by less of toxic side-effects. No-Spa is easily absorbed and exerts a prolonged action. The advantageous properties of the drug assert themselves particularly in the painful affections of the biliary, urogenital and gastrointestinal tract. INDICATIONS: In general, to abolish or prevent pain and dysfunction caused by smooth muscle spasm. Biliary and renal colics, spasms associated with cholecystopathy, cholelithiasis, cholecystitis, nephrolithiasis, pyelitis, cystitis, as well as spasms elicited by instrumental examination. Spastic conditions of the gastrointestinal system; gastric and duodenal ulcer, larÿñgo-, cardio- and pylorospasm, spastic constipation, colitis, proctitis, tenesmus. In acute blood-pressure fluctuations of hypertensives, administered in conjunction with antihypertensive drugs. Coronary and cerebral vascular spasm; intermittent claudication; dysmenorrhoea; to reduce the irritability of the pregnant uterus; in spasm of the uterinal orifice during delivery, protracted first stage of labour, after-pains, threatened abortion, etc.; in case of postoperative wind colics. DOSAGE: The average dose for adults is daily three times 1 to 2 tablets or daily once to three times 2 to 4 ml injected subcutaneously or intramuscularly. In emergency, e.g. acute stone colic, 2 to 4 ml may be given by slow intravenous injection. In case of peripheral arterial spasm or obstruction No-Spa may be injected intraarterially. Children should be given smaller doses according to age and body-weight. Small children should receive once or twice daily ¼ to ½ tablet, older children ½tol tablet daily. In peptic ulcer it is expedient to combine No-Spa with atropine or atropine-like compounds. PACKING: 20 tablets, 40 mg 100 tablets, 40 mg 1000 tablets, 40 mg 5 ampoules, 40 mg (2 ml) 50 ampoules, 40 mg (2 ml) CHINOIN Pharmaceutical and Chemical Works LTD Budapest — Hungary NO-SPA