Antall József szerk.: Pictures from the Past of the Healing Arts / Orvostörténeti Közlemények – Supplementum 5. (Budapest, 1972)

Communicationes de História Artis Medicinae and Libri Históriáé Medicae

LIBEXIN tablets ANTITUSSIVE COMPOSITION: 3-(ß,ß-D¡phenylethyl)-5-(ß-p¡perid¡noethyl)-1,2,4-o×adiazole hydrochloride 100 mg per tablet ACTIONS: Ł¡be×iñ is an antitussive with peripheral point of attack (endoanesthetic) and as such it markedly represses cough stimulus without abolishing it completely. It has no depressive effect on the respiratory centre, it does not diminish the respiratory volume which rather becomes raised. Due to its bronchospasmolytic action, it facilitates breathing, and has a favourable influence on expectoration, too. The antitussive effect of Libexin lasts for about 3 to 4 hours. INDICATIONS: TO RELIEVE COUGHING OF BRONCHIAL ORIGIN: Acute and chronic bronchitis, influenza (grippe), bronchopneumonia, cough due to tumour or some foreign body in the bronchi, bronchial asthma, emphysema, nocturnal coughing of cardiac failure in preparation for instrumental examinations (bronchoscopy, bronchography). TO RELIEVE COUGHING OF PLEURAL ORIGIN

: Dry and exudative pleuritis pleuropneumonia, pulmonary embolism, spontaneous pneumothorax, pleural interventions (surgical pneumothorax, pleural punction, pleural operations). CONTRA-INDICATIONS: Pathological conditions with excessive bronchorrhea, first of all in postoperative condition (after inhalation narcosis). DOSAGE: Average dose for adults is 3 to 4 times daily 1 tablet, in obstinate cases 2 tablets. The usual dose for children is proportionally lower, depending on their age and bodyweight, on the average 3 to 4 times daily V* to ½ tablets. In premedication for bronchological interventions, Libexin should be combined with atropine, and given in doses of 0.9 to 3.8 mg per kg of body-weight one hour before the manipulation. Libexin has no unpleasant side-effects, and causes no habituation. PACKING: 20 tablets, 100 mg 200 tablets, 100 mg NOTE The tablet should be swallowed as a whole or else it may cause temporary numbness and insensitivity of the oral mucosa. CHINOIN Pharmaceutical and Chemical Works LTD Budapest — Hungary