Fogorvosi szemle, 2003 (96. évfolyam, 1-6. szám)

2003-02-01 / 1. szám

20

FOGORVOSI SZEMLE ■ 96. évf. 1. sz. 2003.

5. Dayan D, Bodner L, Horowitz I: Effect of salivary hypofunction on the healing of extraction wounds. J Oral Maxillofac Surg 1992; 50: 354-358.

6. Dignass Au, Sturm A: Peptide growth factors in the intestine. Eur J Gastroenterol Hepatol 2001 ; 13: 763-770.

7. Humphreys-Beher MG, Imell M, Jentoff N, Gleason M, Carlson DM: Isolation and characterization UDP-galactose: N-acetylglucosamine 4ß-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol. J Biol Chem 1984; 259: 5799-5802.

8. Humphreys-Beher MG, Schneyer CA, ZellesT: Alpha-lactalbumin acts as a bimodal regulator of rat parotid acinar cell growth. Biochem Biophys Res Comm 1987; 147:174-181.

9. Humphreys-Beher MG, Zelles T, Maeda N, Purushotham KR, Cassisi N, Schneyer C: Cell-surface galactosyltransférase acts as a modulator of rat and human acinar cell proliferation. Adv Dent Res 1990; 4: 45-60.

10. Humphreys-Beher MG, Zelles T, Maeoa N, Purushotham KR, Schneyer C: Cell surface galactosyltransférase acts as a general modulator of rat and acinar cell proliferation. Molec Cell Biochem 1990; 95: 1-11.

11. Ino M, Ushiro K, Ino C, Yamashita T, Kumazawa T: Kinetics of epidermal growth factor in saliva. Acta Otolaryngol 1993; Suppl. 500: 126-130.

12. Konturen Sj, Dembinski A, Warzecha Z, Brozowski T, Gregory H: Role of epidermal growth factor in healing of chronic gastroduodenal ulcers in rats. Gastroenterology 1988; 94: 1300-1307.

13. Levi-Montalcini R, Cohen S: Effects of the mouse submaxillary glands on the sympathetic system in mammals. Ann N Y Acad Sei 1960; 85:324-341.

14. Lee S-W, Purushotham KR, Littlewood T, Evan G, Zelles T, Blazsek J, Nakagawa Y, Humphreys-Beher MG: Down-regulation of cellular proto-oncogenes during inhibition of rat parotid acinar cell proliferation. Biochem Biophys Acta 1992; 1135:115-122.

15. Lohinai Z, Burghardt B, Zelles T, Varga G: Nitric oxide modulates salivary amylase and fluid, but not epidermal growth factor secretion in conscious rats. Life Sciences 1999; 64: 953-963.

16. Mcinnes C, Sykes Bd: Growth factor receptors: structure, mechanism and drug discovery. Biopolimers 1997; 43: 339-366.

17. Nagy Á, Nagashima H, Cha S, Oxford Ge, Zelles T, Peck A, Humphreys-Beher MG: Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation. Diabetes 2001; 50: 2100-2104.

18. Noguchi S, Ohba Y, Oka T: Effect of salivary epidermal growth factor on wound healing of tongues in mice. Am J Physiol 1991 ; 260: E620-E625.

19. Olsen PS, Poulsen SS, Kirkegaard P, Nexo E: Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 1984; 87:103-108.

20. Olsen PS, Poulsen SS, Therkelsen K, Nexo E: Effect of sialadenectomy and synthetic 1 human urogastrone on healing of chronic gastric ulcers in rats. Gut 1996; 27: 1443-1449.

21. Oxford GE, Kim H, Nguyen T, Alford CE, Tanaka Y, Humphreys- Beher MG: Elevated salivary EGF levels stimulated by periodontal surgery. J Periodontol 1998; 69: 479-484.

22. Oxford GE, Jonsson R, Olofsson J, ZellesT, Humphreys-Beher MG: Elevated levels of human salivary epidermal growth factor after oral and juxtaoral surgery. J Oral Maxillofac Surg 1999; 57:154-158.

23. Purushotham KR, Wang P-L, Dolce C, Zelles T, Blazsek J, Humphreys-Beher MG: Effects of surgical ovariectomy on rat salivary gland function. Archs Oral Biol 1993; 38: 779-784.

24. Purushotham KR, Offenmüller K, Bui At, Zelles T, Blazsek J, Schultz GS, Humphreys-Beher MG: Absorption of epidermal growth factor occurs through the gastrointestinal tract and oral cavity in adult rats. Am J Physiol 1995; 269: G867-G873.

25. Purushotham KR, Zelles T, Blazsek J, Wang P-L, Paul GA, Kerr M, Humphreys-Beher MG: Effect of EGF on rat parotid gland secretory function. Comp Biochem Physiol 1995; 110C: 7-14.

26. Sarosiek J, Feng T, McCallum RW: The interrelationship between salivary epidermal growth factor and the functional integrity of the oesophageal mucosal barrier in the rat. Am J Med Sei 1991 ; 302: 359-363.

27. Schneyer CA, Humphreys-Beher MG: Effects of epidermal growth factor and nerve growth factor on isoproterenol-induced DNA synthesis in rat parotid and pancreas following removal of submandibular-sublingual glands. J Oral Pathol 1988; 17: 250-256.

28. Tepperman BR, Soper BD: Effect of sialoadenectomy on gastric mucosal integrity and growth in the rat. Dig Dis Sci 1990; 35: 943-949.

29. Vinter-Jensen L, Juhl CO, Stubbe-Teglbjaerg P, Poulsen SS, Dajani EZ, Nexo E: Systemic treatment with epidermal growth factor induces ductal proliferations in the pancreas. Gastroenterology 1997; 113: 1367-1374.

30. Vinter-Jensen L: Pharmacological effects of epidermal growth factor (EGF) with focus on the urinary and gastrointestinal tracts. APMIS Suppl. 1999; 107: 5-42.

31. Wang P-L, Purushotham KR, Humphreys-Beher MG: Effect of chronic insulin administration on mouse parotid and submandibular gland function. P.S.E.B.M. 1994; 205: 353-361.

32. Zelles T, Blazsek J, Kóbor A, Gelencsér F: A glandula parotis gusztatórikus ingerrel létrehozott megnagyobbodása. Fogorv Szle 1984; 77: 315-318.

33. Zelles T, Blazsek J, Tófalvy Á, Végh A: A ß-receptor blokkoló Visken hatása a patkány glandula parotisának súlyára, valamint az elválasztott nyál mennyiségére és amiláz aktivitására. Fogorv Szle 1984; 77: 346-348.

34. Zelles T, Purushotham Kr, Macauley SP, Oxford GE, Humphreys-Beher MG: Saliva and growth factors. J Dent Res 1995; 74: 1826-1832.

Nagy G:

Role of saliva, salivary glands and the epidermal growth factor (EGF) on oral wound healing

Saliva perform a number of biologic functions that are instrumental in maintaining oral health. Those are: lubrication, remineralization, buffering, antimicrobial protection, cleansing and maintenance of mucosal integrity. Saliva provides a natural reservoir of growth factors. By far the most highly characterized growth factor is EGF. Animal and human studies suggest that EGF plays a fundamental role in systemic and oral wound healing. This brief review is designed not to discuss all effects of EGF in detail but to highlight the basic principles of growth factors’ action and their role in oral health.

Key words: oral cavity, wound healing, saliva, epidermal growth factor