201768. lajstromszámú szabadalom • Eljárás új cef-3-em-4-karbonsav-származékok és ilyen vegyületeket tartalmazó gyógyászati készítmények előllítására

HU 201768 B

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A példa száma

Vegyület

R2ésR3

Fiziko-kémiai jellemzők

40.

r2=

= 4-CH3 r3= h

NMR (D20) 6:2,0-2,8 (2H, m), 2,60 (3H, s), 3,1-3,6 (2H, m), 3,15 (1H, d, J = 17Hz), 3,62 (1H, d,J = 17Hz), 4,92 (1H, t,

J = 7Hz), 5,21 (1H, d, J = 5Hz), 5,27 (1H, d, J = 15Hz), 5,43 (1H, d,

J - 15Hz), 5,76 (1H, d, J = 5Hz), 6,84 (1H, s), 7,73 (2H, d, J=6Hz), 8,60 (2H,

d, J = 6Hz)

41.

r2=

= 2-CH3

r3= h

NMR (D20) 8: 2,1-2,7 (2H, m), 2,73 (3H, s), 3,1-3,6 (4H, m), 4,90 (1H, t, J = 7Hz), 5,11 (1H, d, J = 5Hz), 5,17 (1H, d, J = 15Hz), 5,42 (1H, d, J = 15Hz), 5,69 (1H, d, J = 5Hz), 6,78 (1H, s), 7,5-7,8 (2H, m), 8,0-8,3 (1H, m), 8,52 (1H, sz, d, J = 6Hz)

42.

r2=

3-CH3

r — h

NMR (D2O) 6:2,0-2,6 (2H, m), 2,45 (3H, s), 3,0-3,7 (4H, m),

4,90 (1H, t, J =7Hz), 5,13 (1H, d, J = 5Hz), 5,15 (1H, d, J = 16Hz), 5,42 (1H, d, J = 16Hz), 5,70 (1H, d, J=5Hz), 6,80 (1H, s), 7,6-7,9 (1H, m), 8,0-8,3 (lH,m), 8,4-8,7 (2H, m)

43.

p2 _ 1-CH2CH3

r3= h

NMR (D2 5:1,27 (3H, t, J = 7Hz), 2,1-2,6 (2H, m), 2,83 (2H, q, J=7Hz), 3,1-3,6 (4H, m), 4,95 (1H, t, J = 7Hz),

4,9-5,6 (2H, m), 5,18 (1H, d, J = 5Hz), 5,73 (1H, d, J = 5Hz), 6,82 (1H, s),

7,79 (1H, d, d, J = 8,5Hz), 8,22 (1H, d, J = 8Hz), 8,59 (1H, d, J=5Hz), 8,63 (1H, s)

44.

R2 = 4--ch2ch3 r3= h

NMR (D2O) 8:1,28 (3H, t, J = 8Hz), 2,1-2,6 (2H, m),

2,88 (2H, q, J = 8Hz), 3,1-3,6 (4H, m), 4,95 (1H, t, J = 8Hz),

4,9-5,6 (2H, m), 5,18 (1H, d, J=5Hz), 5,72 (1H, d, J=5Hz), 6,80 (1H, s), 7,70 (2H, d, J = 8,5Hz), 8,59 (2H, d, J = 8Hz)

45.

r2=

= 2-CH3

r3=

=3-CH3

NMR (D2) 8:2,1-2,8 (2H, m), 2,45 (3H, s), 2,68 (3H, s),

3,0-3,6 (4H, m), 4,95 (1H, t, J=7Hz), 5,15 (1H, d, J=5Hz), 5,25 (1H, d, J = 16Hz), 5,55 (1H, d, J = 16Hz), 5,75 (1H, d, J - 5Hz), 6,83 (1H, s), 7,58 (1H, sz. d, J = 7Hz), 7,08 (1H, d, J=7Hz), 8,41 (1H, d, J = 7Hz)

46.

r2=

=3-CH3

r3=

= 4-CH3

NMR (D2) 8: 2,0-2,7 (2H, m), 2,38 (3H, s), 2,48 (3H, s),

3,0-3,7 (4H, m), 4,97 (1H, t, J = 7Hz), 5,1-5,5 (2H, m), 5,19 (1H, d, J = 5Hz), 6,82 (1H, s), 7,65 (1H, d, J = 7Hz), 8,48,6 (2H, m)

47.

r2=

=3-CH3 R3 =

= 5-CH3

NMR (D2) 8:2,1-2,6 (2H, m), 2,38 (6H, s), 2,9-3,7 (4H, m), 4,89 (1H, t, J=7Hz), 4,8-5,5 (2H, m), 5,11 (1H, d, J = 5Hz), 5,68 (1H, d, J = 5Hz), 6,72 (1H, s), 7,91 (1H, s), 8,33 (2H, s)

48.

R2--r3=

2,3-trimetilén

NMR (D2) 8:2,0-2,7 (4H, m), 2,9-3,6 (8H, m), 4,6-5,6 (3H, m), 5,13 (1H, d, J = 5Hz), 5,74 (1H, d, J = 5Hz), 6,79 (1H, s), 7,56 (1H, d, J=6,5Hz), 8,04 (1H, d, J = 6Hz), 8,35 (1H, d, J=5Hz)

49.

r2_2_-SCH2CH3

r3=h

IRvNujolmax (cm’1): 1780,1690,1610 NMR (D20) 8:1,40 (3H, t, J = 3Hz),2,l-2,6 (2H, m), 3,0-3,5 (6H, m), 4,92 (1H, d,J = 7Hz), 5,08 (1H, d, J = 5Hz), 5,13 (1H, t, J = 15Hz), 5,54 (1H, d, J = 15Hz), 5,70 (1H, d, J = 5Hz), 6,80 (1H, s), 7,35-7,6 (1H, m), 7,69 (1H, d, J=7Hz), 7,95-8,2 (1H, m), 8,50 (1H, d, J = 6Hz)

50.

r2_ 2-■SC2H4NHCHO

r3= h

IRvNujolmax (cm'1): 1775,1690,1610 NMR (D2O) 8:2,05-2,65 (2H, m), 3,05-3,75 (8H, m),

4,91 (1H, t, J=7Hz), 5,09 (1H, t, J=5Hz), 5,13 (1H, t, J = 15Hz), 5,47 (1H, d, J = 15Hz), 5,70 (1H, d, J = 5Hz), 6,80 (1H, s), 7,5-8,25 (3H, m), 7,90 (1H, s), 8,55

(1H, d, J = 6Hz)

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