201067. lajstromszámú szabadalom • Eljárás N-heterociklil-4-piperidinaminokat és e vegyületeket tartalmazó antihisztamin hatású gyógyászati készítmények előállítására

13

HU 201067 B

14

Vegyület L’ R1 R A1=A2-A3=A4 Só/bázis Op. (°C)

száma

109.

4-CI-C6H4-CH2-H-CH=CH-CH=CH-2HBr.H20-110.

4-Br-C6H4-Cll2-H-CH=CH-CH=CH-2HBr.H20

>300

111.

4-CIl3-C6H4-CHz-H-CH=CH-CH=CH-2HBr-112.

4-F-C6H4-CH2-H-CH=CH-CH=CH-2HBr

290.2

113.

H

n-C4H9--CH=CH-CH=CH-2HBr.H20

223.1

114.

2-F-C6H4-CH2-H-CH=CH-CH=CH-2HBr-115.

CcHs-CHz-H-CH=CH-C(CF3)=CH-2HBr-116.

C6H5-CH2-H-CH=CH-C(C1)=CH-2HBr

>260

117.

C6H5-CH2-H-N=CH-CH=CH-2HCI.H2O

298.1

118.

4-F-C6IU-CH2-H-CH=CH-C(C1)=CH-2HBr

>260

119.

4-F-C6H4-CH2-H-CH=CH-C(CH3)=CH-CH=C(CH3)-CH=CH-2HBr

'

120.

4-F-C6H4-CH2-H-CH=CH-C(F)=CH-CH=C(F)-CH=CH-2HBr

285.6

121.

C6H5-CH2-H-CH=CH-C(CH3)=CH-CH=C(CH3)-CH=CH-2HBr

'

122.

CsHs-CHz-H-CH=CH-C(F)=CH-CH=C(F)-CH=CH-2HBr

>260

123.

4-F-C6H4-CH2-H-N=CH-CH=CH-2HCI.H2O

269.7

124.

CsHs-H-CH=CH-CH=CH-2HBr.H20

>300

125.

4-F-C6H5-H-CH=CH-CH=CH-2HBr

>300

126.

4-N02-C6H4-CH2-H-CH=CH-CH=CH-2HBr.H20-127.

2-CH3.4-F-C6H3-CH2-H-CH=CH-CH=CH-2HBr

—

128.

C6H5-C2H4-H-CH=CH-CH=CH-bázis

181.8

129.

3-F-C6H4-CH2-H-CH=CH-CH=CH-bázis

218.4

131.

2-piridil-metil-H-CH=CH-CH=CH-3HBr

295.9

132.

3-piridil-metil-H-CH=CH-CH=CH-3HBr

>260

133.

5-CH3-4-imidazolil-metil-H-CH=CH-CH=CH-2HBr

272.1

134.

2-pirazinil-metil-H-CH=CH-CH=CH-3HBr-135.

4-F-C6H4-CH2-H-CH=CH-CH=N-2HBr

300.6

136.

furfuril-H-CH=CH-CH=CH-bázis

211.0

137.

4-F-C6H4-CH2-H-CH=CH-CH=CH-bázis

215.5

138.

4-F-C6H4-CH2-H-CH=CH-N=CH-2HBr

279.4

139.

2-piridil-metil-H-N=CH-CH=CH-3HBr

265.5

140.

furfuril-H-N=CH-CH=CH-bázis

159.0

141.

4-F-C6H4-CH2-H-CH=N-CH=CH-2HBr.H20

291.6

142.

4-F-C6H4-CH2-H-CH=C(F)-C(F)=CH-2HBr

210.6

144.

2-tienil-metil-H-CH=CH-CH=CH-bázis

146.

3-furil-metil-H-CH=CH-CH=CH-bázis-147.

5-metil-furfuril-H-CH=CH-CH=CH-bázis-148.

2-tienil-metil-H-N=CH-CH=CH-bázis

189.6--193.5

149.

4-tiazolil-metil-H-C!I=CH-CH=CH-2HBr.2HzO

223.5

150.

4-CH3O-C6H4-CH2-H-CH=CH-CH=CH-bázis

178.1

151.

4-F-C6H4-CH2-H-Cll=CH-C(OCH3)=CH-bázis-152.

4-F-CCH4-CH2-CH3-CH=CH-CH=CH-2HC1-H20

222.2

153.

4-F-C6H4-CH2-H-CH=C(OCH3)-CH=CH-bázis-154.

H

C6HS-CH2-CH=CH-CH=CH-bázis-155.

3-CI-C6H4-CH2-H-CH=CH-CH=CH-2HBr

262.2

156.

3,4-(CH3)2--C6H3-CH2-H-CH=CH-CH=CH-2HBr-9