200455. lajstromszámú szabadalom • Eljárás pirimidin-származékok előállítására

5

HU 200455 B

6

Q

X

Y

Z

ICso(juM)

H

H

H

H

4.50

H

CH3OH

H

3.60

H

XÍOH

H

2.10

H

C2H5OH

H

8.50

H-tíCHzNHH

H

1.00

H

(CH3)2NH

H

1.95

H

£fcH20-H

H

1.10

H

CH3OH

CH3O-3.30

H

J0NHH

H

1.40

H--0N(CH3)

H

H

2.50

H-efCHzN(CH3)H

H

2.80

H-NH2

H

H

1.50

H-CH3

H-CH3

12.50

H

Í7-C3H7OH

H

2.60

H

(C2Hs)2NH

H

3.90

H

OH

H

2.80

H

OH

H

2.40

H

(n-C3H7)2NH

H

3.70

H-CH3

H

C2H5O-11.00

H

CíHuOH

H

2.70

Cl

H

H

H

14.50

H

D»

H-CH3

5.20

H

(CH3)2NH

H

7.00*

H-CH3

H

H

4.00

H

H

Cl

H

6.80

H-CH3

H-CzHs

27.00

H

CH3O-CH3

H

6.10

H

/Í-C4H9OH

H

2.70

(CH3)zNH

H

H

5.30

H

H

Br

H

6.90-NH2-CH3

H

H

24.00

CH3CONH-CH3

H

H

46.00

H-CH3

H

CH3O-7.80

H

Í-C3H7O

H

H

3.70

Cl

CH3OH

H

5.10

Cl

C2H5OH

H

6.30

(CH3)zN-CH3

H

H

8.30

F-CH3

H

H

10.00

Cl-CH3

H

— Clí 3

6.10

H

CH30(CH2)20-H

H

5.80

H

C2H50--CH3

H

2.70

Cl

C2H5

H

CH3

4.50

(CH3)2N—CÍÍ3

H

CIl3

3.80

H

H-CII3

11

27.00-NH2-CH3

H-Cll3

19.00*

* a meghatározást 7,5 pH-értékben végeztük.