199803. lajstromszámú szabadalom • Eljárás 1-acil-2,3-dihidro-4(1H)-kinolin-4-oxim-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására

1

HU 199803 B

2

Pl.

Vegy. R1

R5

IRlKBr.cm'1)

NMR(DMSO-d6, ppm)

Boml.

sz.

sz.

CC)

146-OCH3

6-C1

1710,1400,

2,78(2H,t),3,70(3H,s),

185,0

1250

3,78(2H,t),7,31-7,85 (3H,m)

147-CH3

6-C1

1660,1400,

2,21 (3H,s),2,79(2H,t),

152,8

”

1240

3,80(2H, t),7,40-7,85 (3H,m)

148-CH2CH3

6-a

1660, 1395,

0,97(3H,t),2,49(2H,q),

204,7

2

1285

2,70(2H,0,3,74(2H ,t), 7,25-7,8 l(3H,m)

149-(CH2)3CH3

6-C1

1660,1270,

0,86(3H,t), 1,27(2H,m),

137,8

1245

1,42(2H,m),2,49(2H,t),

2,76(2H,t),3,79(2H,t),

7,31-7,86(3H,m)

150-(CH2)?CH3

6-a

1670,1395,

0,87(3H,t),l,00-1,82

123,0

1260

(12H,m),2,56(2H,0,

“

2,73(2H,0,3,77(2H,0,

7,26-7,85(3H,m)

151-CH2CH(CH3)2 6-C1

1655,1390,

0,88(6H,d),2,39(2H,d),

139,3

1250

2,72(2H,0,3,23( 1 H,m),-3,77(2H,0,7,26-7,79 (3H , m)

152-C(CH3)3

6-a

1640,1405,

l,29(9H,s),2,73(2H,0,

170,5

"

1240

3,83(2H,0,7,25-7,75

(3H,m)

153-CH2CH2C1

6-a

1655,1400,

2,76(2H,0,3,04(2H,0,

192,9-1245

3,06(2H,0,3,80(2H,t),

7,32-7,86(3H,m)

154-C(CH3)2-6-a

1650,1400,

1,37(6H,s),2,76(2H,0,

187,8-CH2

C1

1260

3,78(2H,s),3,84(2H,0,

7,26-7,75(3H,m)

155-CH2CH2-6-ci

1740,1680,

2,76(2H,0,3,29(4H,s),

140,7-C02

CH3

1285

3,53(3H,s),3,89(2H,0,

7,32-7,90(3H.m)

156-CH20CH3

6-a

1660,1410,

2,80(2H,0,3,29(3H,s),

210,7

“

1230

3,73(2H,0,4,26(2H,s),

7,34-7,89(3H.m)

157- -<]

6-a

1660,1420,

0,89(4H,m), 1,98( 1 H,m),

221,7

1260

2,72(2H,0,3,86(2H,0,

7,42-7,82(3H,m)

158-6-ci

1650,1400,

1,09-1,87(1 lH,m), 2,70

167,9

1260

(2H,t),3,79(2H,0,

7,41-7,83(3H,m)

159-Ob-Q

6-a

1660,1390,

2,66(2H,0,3,79(2H,0,

155,7

1240

3,88(2H,s),7,05-7,79

(8H,m)

160-ch=ch^>

. 0

6-a

1650,1380,

2,78(2H,0,3,90(2H,t),

169,5

1215

6,98( 1 H,d),7,60( lH,d), 7,30-7,87(8H,m)

161

6-a

1645,1380,

2,81 (2H,0,3,82(2H,0,

185,7

1250

6,817,8 l(8H,m)

162-6-a

1660,1385,

2,86(2H,0,3,83(2H,t),

231,8

1280

6,89-8,52(7H,m)

163

6-a

1640,1420,

2,83(2H,0,3,93(2H,0,

199,4-0

1280

6,90-7,30(4H,m),7,66-7,85(2H,m)

164

6-a

1640,1480,

2,82(2H,t),3,46(3H,s),

107,2

1280

3,63(2H,t),6,80-7,85

H3

CO

(7H,m)

165

^Q-°CH3

6-a

1640,1380,

2,81(2H,t),3,70(3H,s),

130,1

1250

3,83(2H,t),6,70-7,76

(7H,m)

18