199803. lajstromszámú szabadalom • Eljárás 1-acil-2,3-dihidro-4(1H)-kinolin-4-oxim-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására
1 HU 199803 B 2 Pl. Vegy. R1 R5 IRlKBr.cm-1) NMR(DMSO-d6, ppm) Boml. sz. SZ. CC) 166 o or 6-C1 1655,1480, 2,82(2H,t),3,62(2H,t), 151,8-1240 7,15-7,90(7H,m) 167 6-C1 1655,1380, 2,83(2H,t),3,82(2H,t), 207,3 9 a 1280 6,78-7,80(7H,m) 168-CH2 CH3 6-Br 1660,1400, 1,02(3H,t),2,47(2H,q), 206,8-1260 2,73(2H,t),3,76(2H,t), 169-~Ç)~ a Cl-CH2CH3 6 6-F 1655,1495, 1280 7,45-7,92(3H,m) 2,81(2H,t),3,53(2H,t), 7,29-7,67(6H,m) 159,0 170-OCH3 1640,1400, 1,01 (3H,t),2,47(2H,q), 159,6 1245 2,71 (2H,t),3,72(2H,t), 3,76(3H,s),6,83-7,45 (3H,m) 171-CH2 CH3 6-H 1660,1400, 0,99(3H,t),2,43(2H,q), 90,5 1250 2,72(2H,t),3,73(2H,t), 7,12-7,89(4H,m) 172 5-a 1650,1450, 2,93(2H,t),3,80(2H,t), 229,0-1250 6,60-7,45(7H,m) 173-CH2 CH3 5-C1 1655,1395, 1,00(3H,t),2,44(2H,q), 126,2 ” 1250 2,83(2H,t)3,69(2H,t), 7,32(3H,m) 174-C(CH3)3 5-C1 1650,1400, 1,23(9H,s),2,83(2H,t), 178,0 1-9 1270 3,77(2H,t),7,25(3H,m) 175 5-a 1650,1380, 1240 2,24(3H,s),2,97(2H,t), 3,80(2H,t), 146,2 h3 c 6,86-7,44(7H,m) 176 9 6-C1 1640,1370 2,23(3H,s),2,84(2H,t), 174,7-1235 3,82(2H,t), h3 c 6,97-7,96(7H,m) 17. Táblázat (Xm) általános képletű vegyületek Pl. Vegy. R1 R5 IRCKBr.cm-1) NMR(DMSO-d6, ppm) Boml. sz. sz. (°C) 177 ~çyci 8-C1 1665,1395, 1250 2,82(2H,t),3,55(2H,t), 7,05-7,95(6H,m) 207,0 Cl 178-CH2 CH3 8-C1 1660,1380, 0,99(3H,t),2,47(2H,q), 150,0 “ 1240 2,74(2H,t),3,48(2H,t), 7,10-7,85(3H,m) 179-C(CH3)3 8-C1 1660,1280, 1,32(9H,s),2,77(2H,t), 187,6 5-Oa 1250 3,80(2H,t),7,05-7,82 (3H, m) 180 8-C1 1650,1450, 2,80(2H,t),3,27(2H,t), 170,6-1280 7,12-7,90(7H,m) 181-CH2 CH3 7-C1 1660,1395, 1,02(3H,t),2,48(2H,q), 152,1 3 1245 2,77(2H,t),3,76(2H,t), 7,15-7,96(3H,m) 182-C(CH3)3 7-C1 1650,1395, 1,30(9H,s),2,76(2H,t), 247,3 4 1240 3,87(2H,t),7,10-7,90 (3H,m) 183-C(CH3)2-7-C1 1660,1415, 1,38(6H,s),2,77(2H,t), 170,6-CH2 C1 1255 3,83(2H,s),3,88(2H,t), 7,10-7,88(3H,m) 19
