194891. lajstromszámú szabadalom • Eljárás 6-(triszubsztituált-metil)-penicillánsav- és származékaik előállítására

194891

(1XVT)

(LKVTI)

(LXIII)

(LXIX)

(LXX)

49

50

Termelés

1H-NMR(CDC1,)ppm(delta)

7,

5

0.98 (t,

3H), 1.5 (s, 3H), 1.7 (s,

(6ß,

BR)

3H) ,

, 1.87 (m, 2H), 4.0-4.4 (m, 2H),

4.4-■4.6

(m, 2H), 4.68 (d, 2H), 5.2-5.5

(m.

3H), 5.7 (m, 1H), 5.84-6.00

(m,

1H) ,

7.2-7.3 (m, 3H), 7.66-7.8

1 b

<m,

1H) .

1.0

(t,

3H) , 1.40 (s, 3H), 1.64 (s,

(6ß,

8S)

3H1 ,

1.9

(m, 2H), 4.05 (m, 1H), 4.3

(m,

1H) ,

4.5 (s, 1H), 4.6-4.7 (m, 3H),

5.2-•5.4

(m, 4H), 5.6 (d, 1H), 5.84-6.00

1 (m.

1H) , 7.1-7.3 (m, 3H) , 7.6

(m,

1H) .

30

1.44

(s,

3H), 1.64 (s, 3H), 4.3 (dd,

sarga olaj

1H) ,

4.65 (s, 1H), 4.66 (d, 2H), 5.2-5.6

(m,

3H), 5.62 (d, 1H), 5.8-6.1 (m,

1H) ,

7.32-7.42 (m, 2H),, 7.52-7.64 (m,

1H) ,

7.7-8.2 (m, 1H).

sárga 1

olaj

1.38

(s,

2.4H), 1.48 (s, 0.6H), 1.6

13

Is»

2.4H), 1.67 (s, 0.6H), 3.7 (s,

(6ß,

8S) és

0.6H), 3

.74 (s, 2.4H), 4.12 (dd,

(6ß,

8R)

0.2H), 4

.34 (dd, 0.8H), 4.4 (s, 0.2H),

4:1 arányú elegye

4.44

(s,

0.8H), 4.63 (m, 2H), 5.1-5.36

3.2H), 5.42 (d, 0.8H), 5.8-6.0 (m,

1H) ,

6.8-7.3 (m, 2H).

27

1.3

(s,

3H), 1.56 (s, 3H), 3.0 (s,

(6ß,

8S)

3H) ,

4.45 (s,. 3H), 4.6 (m, 2H) , 4.66

(•Id,

1H)

/5.0 (d, 1H), 5.2-5.4 (m,

24) ,

5.4

(d, 1H), 5.8-6.0 (m, 1H),

6.76

(s,

1H), 7.1-7.5 (m, 3H), 7.5-7.7

(tn,

2H) .

13

1.5

(s.

3H>, 1.68 (s, 3H), 3.28 (s,

(6ß,

8R)

3H) ,

4.36 (dd, 1H), 4.44 (s, 1H), 4.66

(m,

2H) ,

5.14 (d, 1H), 5.24-5.5 (m,

2H) ,

5.7

(d, 1H), 5.8-6.0 (m, 1H), 6.9

(s,

1H) ,

7.2-7.5 (m, 3H), 7.6-7.8 (m.

;hi

.

18

1.3

(s,

3H), 1.58 (s, 3H), 2.25 (s,

(6ß

, 8S)

3H) ,

2.3

(s, 3H), 3.65 (s, 3H), 4.45

's,

1H) ,

4.54 (dd, 1H), 4.6 (m, 2H),

5.2-5.4

(m, 3H), 5.48 (d, 1H), 5.8-6.0

(m.

1H) ,

6.77 (s, 1H), 7.26 (d, 1H).

1.44

(s.

'3H), 1.62 (s, 3H), 2.18 (s,

65

26