191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

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///. táblázat folytatása

Vegyidet u v w x y z IR NMR

száma

l

3-53 H H NH2CO F -CH

I

Ph2

3-54 H H HjNCO F -CH

/ I

Ph,

3-55 H H -CO F -CH

I I

NHCH3 Ph2

3-56 H H -CO F -CH

I I

NH2 Ph2

3-57 H H H F -CH

!

Ph2

3-58 H H H F -CH

I

Ph2-STetCH2CH2OCOO

1

CHCI3 :

(p-CH3)PhCH2

3500,3400, 1780,1740

2,33 (s, 3H), 3,52 (s,5H), 4,10-4,70 (m, 8H), 5,07 (s, 3H), 5,83-6,27 (m, 2H), 6,90 (s, 1H), 6,62-7,70 (m, 16H)

-STetCHíCONHj

KBr:

Aceton-d6:

3375,1785, 1680,1660

3,52 (s, 3H), 3,70 (s, 2H), 4,20-4,40 (m, 2H), 4,62 (bs, 2H), 5,12 (s, 3H), 6,70-7,77 (m, 16H)

—STetCH2Cll=CH2

CHClj :

2,90 (d, 3H, 3 =4), 3,58 (s,5H),3,70 (s,2H),4,7(s,2H), 4,83 (s, 1H), 5,0- 6,2 (m, 5H), 6,95 fs, 1H), 6,5-7,8 (m,13H)

STeCH2C!l=CH2

CHCI3 :

CDCI3:

3500,3400, 1785,1700, 1630

3,5? (s, 5H), 4,26 (s, 2H),4,5-6,2 (m, 9H),6,70(s, 1H), 6,89 (d, 1H, J = 36), 7,2-7,9 (m, 11H)-STeCH2CH=CH2

Nujol:

CDCI3 :

3200,3160, 1780,1725, 1650

3,38 (s, 2H), 3,55 (s, 3H), 4,6—6,1 (m, 8H), 6,66 (dd, ÍH,J = 81,5), 6,90 (s, 1H), 7,2-7,6 (m, 1III)-STeiCH2CONH

1

CHCI3:

Aceton-d6:

1

HjNCO C'II2

3350,1785, 1710

3,55 (s, 511), 3,92 (d, 2H, J = 6), 4,26 (s, 2H), 4,63 (s, 2H), 5,14 (s, 1H), 5,23 (s, 2H), 5,77 (dd, 1H, J = 40,5) 6,93 (s, 1H). 6,3- 8,3 (m, 15H)

35