191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

191 378

HL táblázat folytatása

száma

3-59 H H H F -CH

I

Ph2

3-60 H H H F -CH

I

F!i2

3-61

II

1!-CO F 1

cn

1

1

NHCIIj

Pih

3-62

H

H-CO

1

F-Cil

1

!

NHj

Ph2

3-63

H

H-CO

F-CH

NHCHj Phj

7

IR

NMR-SletCHiCONH

1

CHClj :

CDCI3-CD3OD:

!

H,NCO

3500,3330, 1785,1720

3,40 (s, 2H), 3,55 4,15 (s, 2H),4,55 (s, 2H), 5,07 (s, 2H),5,10(s, 1H), 5,52 (dd, 1H, J = 40,5), 6,69 fdd, 1H, J = 81.5),

6,88 (s, 1H)" 7,2— 8,3 (m, 14H)

airirio 4-oxo-üazeim-5 •

CHClj :

CDCi3 :

■í ín zolil-tio

3320,1785, 1720

3,41 (s, 2H), 3,58 (s, 3H), 4,25 (s, 2H), 4,48 (s, 2H). 5.08, 5,10 (s, 1H), 5,52 (dd, 1H, J = 40,4), 6,70 (s, 1H), 6,90 (s, 1H), 6,4— 7,7 (m, 14H)

S'I clCIIjCONIIj

KBr:

3430,334ö, 1780,1715, 1685,1670

DMSO-dó:

2,67 (d. 3H, J = 5). 3,42 (s, 3H), 3,65 (s,2H), 4,10-4,43 (m, 2H), 4,47- 4,78 (m, 2H), ■

5,03 (bs, 2H), 5,17 (s, ÍH), 6,88 (s,lH), 6,65-8,33 (m,

*4H)

SíctCHjCONH

I

KBr:

,4cetor. -do:

!

ch3

3380,1786, 1720,1780, 1630

2,77 (d, 3H, J =

9), 3,55 (s, 3H), 3,72 (s, 2H), 4,22 (bs,2H),4,63 (bs, 2H), 5,07 (s, 2H), 5,13 (s, 1H), 6,90 (s, III), 6,70-7,77 (m,15H)

Sí cíCHjCHjO 1

CHCI3 :

CDCI3 :

i

Cl!., PhCII2OCO

3440,3350, 1785,1740, 1685,1635

2,32 (s, 3H), 2,82 (d,2H, J=55), 3,55 (s,5H). 4,13-4,73 (m, 8H), 5,07 (s, 3H), 6,08-6,50 (m, 1H), 6.83 (d, 1H,

J = 34), 6,90 (s, 1H) 7,00-7,67 (m,

15H)

36