191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

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II. táblázat folytatása

Vegyület u v w x y z IR NMR

száma

2-31 H Cl H Cl H

2-32 Ph H H Cl H

2_33 -CONHjH

H

Cl

H

2-34 -COONa H

H

Cl

Na

2-35 2,3-di- H

H

Cl

H

oxo-4-etil-piperazin-l-ilkaronilamino-2->-36 N3 H H Cl H

2-37 -S-CH2OH Cl H

-STe-.CHa Nujol:

1765,1705, 1670,1625

Aceton-d6:

3,48 (s, 3H), 385 (s, 2H), 3,98 (s, 311), 4,33 fs, 2H), 4,50 (s, 211), 5,08 (s, 1H), 6,73 (s, 1H), 7,78-8,33 (m, 2H)-S'IeXIb KBr:

1775,1680

Aceton-d6:

3,32+3,47 (s, 3H), 3,95 +

3,98 (s,3H), 4,30 (bs, 2H), 4,58 (s, 1H), 4,67 (s, 1H),

5,08 (s, 111), 5,20 (s, 1H),

6,20 (d, 1H, J = 7), 6,67 (d, 1H,J = 7), 7,20-7,70 (m, 5H), 8,30 (br, 1H)-STetCHs

Aceton-dő+Dj 0:

3,50 (s, 311), 4,00 (s, 3H), 4.35 (s, 2H), 4,67 (s, 2H), 5,12 (s, 1H), 6,32 (d, 1H,

J = 6,5) 6,83 (d, 1H, J =6,5)-STetCHj

TLC (n-Bu0H:H20 = 7:3): Rf = 0,6

—SietCH3 Nujol:

3200,1780, 1700,1670,

Aceton-dó:

1,18 (t, 3H, J - 8), 3,52 (s, 3H), 4,00 (s, 311), 3,5-4,2 (m, 611), 4,33 (s, 211), 4,67 (s,2H), 3,54+3,46 (s, 1H), 5,95 (d, 1H, J = 7), 6,22+6,40 (d, 1H, J = 6), 6,80 (d, 1H,

J = 6), 10,06 (d, 1H, J = 7)-STetCHa Nujol:

3170,2100, 1780,1700

Aceton-d6:

3,52 (s, 3H), 3,98 (s,4H),

4,33 (s. 211). 4,68 (s,2H), 5,12 (s, 111), 5,07+5,10 (d, 1H,

J = 7), 6,87 (d, 1H, J = 7)-STetCHa

Aceton-d6+CD3OD = 4:1 3,52 (s, 311), 4,00 (s, 2H), 4,33 (s, 2H), 4,67 (s, 2H), 5,08 (s, Hl), 5,13 (s, 1H)

2—38 -S-CHO Cl 11 -STotCllj Aceton-d6:

3,52 (s, 3H), 3,98 (s, 3H),

4,35 (s, 211), 4,68 (s, 2H), 5,17 (s, 111), 5,63 (s, 1H),

9,23 (s, III)

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