191378. lajstromszámú szabadalom • Eljárás vinil-tio-acetamido-oxa-cef-3-ém-4-karbonsav-származékok előállítására

191 37ö

II. táblázat folytatása

Vegyület

száma

u V

w

X

y

z

ÏR

NMR

2-39-S-conh2

Cl

H-STetCH3

KBr:

3430, 3330, 3210,1785, 1700,1655

CD3OD-Aceton-d6 = 1:4 3,52 (s, 3H), 4,00 (s, 3H), 4,32 (s, 2H), 4,67 (S, 2H), 5,13 (s, 1H), 5,18 (s, 1H)

2-40-5--GOGH

F

11-SlctCHj

KBr:

3430,1785, 1615

2—41-S-COOH-SCH a

H

S í \‘íCH3

KBr.

1780,1690, 1520

CDCI3+CD3 OD:

2,23 (s, 3H), 3.58 (s, 3H), 3.95 (s, 3H), 4,32 (s, 2H), 4,63 (s, 2H), 4,77 Is, 1H), 5,10 (s, 1H)

2-42-S-COOH-SPh

H-STetCHj

KBr:

1782,1690

CDCI3+CD3OD:

3.56 (s.3H), 3.94 (s.3H), 4,30 (s, 2H), 4,60 (s, 2H), 4,79 (s, 1H), 5,09 (s, 1H), 7,27 (s, 5H)

2-43-S-COOH-schf2

H

—STetCHj

KBr:

3440,1772, 1685

CDCI3 +CD3 OD+DMSO d6: 3,53 (s, 3H), 3,96 (s, 3H), 4,35 (s, 2H), 4,57 (s, 2H), 5,00 (s, 1H), 5,05 (s, 1H), 6.89 (t, 1H, J = 59)

2-44-S-COOH

Cl

II-SlelCHj

KBr:

3430,1780

Aceton-d6:

5,25 (s, 1H), 5,12 (s, 1H), 4,67 (s,2H), 4,33 (s, 2H), 3,98 (s, 2H), 3,50 (s, 3H),

2-45-s-COOH

Cl

H

SlctCHj

C!í2OCO

1

CljCH

KBr:

3200-3400, 1780,1700

Acetori-d6:

3,52 (s, 311), 4,21 (s, 2H), 4,37 (s, 2H), 4,66 (s, 4H). 5,14 (s, 1H), 5,27 (s, 1H), 8,50 (s, 1H)

2-46-s-COONa

Cl

Na

(a)

KBr:

CD3OD:

3340. 3190, 3,52 (s, 3H), 4,22+4,52 (ABq,

1766, 1680, 2H, J = 12), 4,53 (s, 2H), 5,03

1635, 1600 (s, 1H), 4,87 (s, 1H), 6,37

(s,lH)

18