186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására
1 2 186 583 3, táblázat folytatása Pld. ÍR (KBr): cm" 3540,3360,2980,1715, 2. 1690,1495,1355,1340, 1210,1105,1090,830, 805. 790,755,710.. lH NMR (90 MHz, CDCU): ő ppm 2.38 (s, 3H), 3,72 (s, 6H), 5.2 (s, 1H). 5.35 (s, 2H), 5.4 (s, 2H), 7.3-8.25 (m, 5H) 3540,3380,3000,1710, 3. 1690,1490,1355,1335, 1210,1105,1090, 790, 760,720 1.23 (t, J = 7 Hz, 6H), 2.4 (s, 3H), 4.18 (q, J = 7Hz, 4H), 5.2 (s, 1H),5.3 (s,2H), 5.4 (s, 2H), 7.2—8.2 (m, 5H) 3450, 3350,2980,1705, 1685,1530,1485,1350 4. 1205.1100.1080.780,715 1.4 (t, J = 8Hz, 3H), 1,27 (d, J = 6Hz, 6H), 1.42 (s, 3H), 4.15 (q, J = 8 Hz, 2H), 5.0 (sep, J = 6 Hz, 1H), 5.14 (s, 1H), 5,3 (s, 2H), 6,1 (m, 2H), 7,5-8.4 (m, 5H) 3420,2960,1740,1710, 1685,1645,1600,1530, 5. 1475,1350,1320,1205, 1070.900.830.755 2.44. (s, 3H), 3,7 (s, 3H), 3.7 (t, J = 6Hz, 2H), 4.36 (t, J = 6 Hz, 2H), 5.1 - 5.8 (br. s 2H), 5.2 (s, 1H), 5.33 (s, 2H), 7.45-8.3 (m, 5H) 6. 3500,3400,3000,1710 1690,1640,1600,1530, 1490,1350,1210, 1100, 900,780,760, 720 0.8 (t, J = 7Hz, 3H), 1.46 (q, J = 7Hz, 2H), 2,35 (s, 3H), 3.3 (J = 7Hz, 2H), 3,5 (t, J = = 6Hz, 2H), 3,75 (t, J = 5Hz, 2H), 4.1 (t, J = 6Hz, 2H), 4,24 (t, J = 5Hz,2H),4,92 (d, J = 12Hz, 1H), 5,05 (s, 1H), 5,06 (d, J = 12Hz, 1H), 6,6 (széles - s, 2H), 7,3- 8.1 (m, 4H), 9,0 (s, 1H) 4. táblázat Pld. sz. Szerk. képlet kiterm. ■ a számított %-ában olvadás pont °C uv MeOH X nm max, N02 C,H5OOC-YT COOCjHs ch3 h CH20-C0NH-CH3 260 mg 42% 192-193 235 355 1 NO, CH3OOC-v^V^ COOCHa A NA ch3 h ch2 0-C0NH-CH3 200 mg 39% 151-153 235 355 10 CÍÍ3>CHOOCCH3 CH3 'NH CH20-C0NH-CH3 250 mg 26% 194-196 235 355 11 12 no2 CI-CHîCHjOOCv^1- ^ COOCH ÄN ch3'xh CH20-CONH-CH 420 mg 72% 194-195 cÍ?3>CH00C Y"X no2 cooc2h5 Cils CH2 0-C0NH-C2H5 370 mg 78% 153-154.5 236 355 235 355 10
