186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására
1 2 836 582 4. táblázat folytatása Pld. sz. IR (KBr): cm'1 1HNMR (90 MHz): 6 ppm 8 3400, 3300, 3000,1690, 1685,1480,1355,1280, 1205,1105.790. 760. 720 (b), 1.18 (t, J = 7Hz, 6H), 2,38 (s, 3H), 2.67 (d, J = 5Hz, 3H), 4.12 (q, J = 7Hz, 4H), 5.13 (s, 3H), 7.22 (m, 1H), 7.5 -8.3 (m,4H), 9,13 (s, 1H) 9 3350, 2950, 1700,1685, 1530,1480,1350, 1210, 1095.780.705 (a): 2.38 (s, 3H), 2.88 (d, J = 5Hz, 3H), 3.72 (s, 6H), 5.2 (s, 2H), 5.4 (s, 2H), 7.35 -8.3 (m,5H) • 10 3380, 3290, 2980, 1680, 1525,1480,1350,1275,1250 1205,1100,780,715 (b): 1,0-1.3 (m, 9H), 2.38 (s, 3H), 2.67 (m, 3H^Tnq7r^HT2HP^I^e^ J = 6Hz, 1H), 5.1 (s, 3H), 7.2 (m, 1H), 7.4 - 8.2 (m,4H),9.1 (s, 1H), 11 3400, 3300, 2960, 1690, 1640, 1610,1530,1480, 1350,1280,1260,1210, 1110,905, 830,780,, 760, 71 í (a); 2,47,(s, 3H), 2.85 (d, J = 5Hz, 3H), 3.73 (s, 3H), 3.75 (t, J = 6Hz, 2H),4.4 (t, I ='6Hz, 2H), 5.22 (s, 1H), 5.34 (s, 2H), 6.7 (q, J = 5Hz, 1H), 7.45 -8.5 (m, 5H) 12 3350,2980,1685,1530, 1480,1350,1275,1250, 1205,1095,780,715 (b): 0,9-1.3 (m, 12H), 2.34 (s, 3H), 3.07 (q, J = 7ttz, 2H), 4.07 (q, J = 8 Hz, 2Ü), 4.9 (m, 1H), 5.06 (s, 3H), 7.28 (t, J = 7Hz, 1H), 7.5 (8.2 (m,4H), 9.05 (br. s 1H) * : (a): CDCl^ (b): DMSO-d6 4. táblázat (folytatás) Pld. sz. Szerk. képlet ki term, a számított %-ábari olvadás pont °C------DV-----XMe0Hnm max, 13 QT N°2 WpCHOOC COOC2H; 3 InA CH3 "V ^ CH2 O-CONH-Cs h7 440 mg 90% 150,5-152 ■ 235 355 14 r^Y NOí CH U Jj r„>CHOOC- AX. COOC2H5 3 T n if ^ CH3 AHa CH20-eONH<H) 330 mg 62% 157-159,5 235 355 15 fY NOí CH, *V pipCHOOC COOC2H5 A NiC ~ CH3 ^ H ^ CH20-CONH-<Q> 370 mg 71% 134-136 238 356 . 16 fT NOj CH^HOOC- VA COOC2H5 T NÏÏ CH3 ^ CH2 O-CONH—<^-Cl 390 mg 70% 113-116,5 235 355 17 NOí Cl-CH2CH2OOC- V cooch3 1 nY ch3 A h - a CH20-CONH-OC1 450 mg 65%-243 355 11
