186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására
1 2 186 >83 5. táblázat ■'folytatás') Pld. sz. ÍR (KBr): cm'1 1H NMR (90 MHz, DMi>0-d6): 5 ppm 29 3$oö. 34oo, 3öoo,i69ö, 1640,1610,1530,1585, 1350.1330,1280,1210, 1110.1095,905, 830, 780, 755,720 0.85 (t, J « Stíz, 3W), 1.13 (t, J = étit, 3H), 1.5 (m, 2hT>, 2.38 (s, 3H), 3.36 (t, ) = 8Hz, 2H), 3.55 (t, J - 4Hz, 2H), 4.03 (q, J = 8Hz, 2H), 4.15 (t, J = 4Hz, 2H), 4.9 (d, J = 12Hz, 1H), 5.02 (s, 1H), 5.05 (d, J = 12Hz, 1H), 6.6 (s, 2H), 7.42 (d, J = 9Hz, 2H), 8.1 (d, J = 9Hz, 2H), 8.49 (s, 1H) 30 3540, 338Ô, 3000,2230, 1710, 1690,1640,1605, 1490.1120.1090.1040, 1200.1120.1090.1040, 940, 840, 775, 136 (s. 3H), 3.28 (s, 6H), 3.53 (t, J = 4Hz, 4H). 4.18 (t, J = 4Hz, 4tí), 4.97 (d, J = 13Hz, 1H), 5.13 (d, J = 13Hz, 1H), 5.25 (s, 1H), 6.73 (br. s, 2H), 7.3-7.9 (m, 5H), 8.97 (s,lH) 31 3420,3350,2980, 1?2Ö, 1680,1605,2490, 1380, 1320,1280,1210,1110, 1095,860, 750 126 (s, ShrænrSRT 3.5 (t, J = 4ÍIz, 4H), 3.7lsT3H), 4.08 (t, J = 4Hz,4H), 4.88 (d, J = 12Hz, 1H), 5.02 (d, J = 12Hz, 1H), 5.2 (s, 1H), 6.58 (s,2H), 677-7.3 (m, 5H), 7.57 (s, 1H) 32 3420,2980,1703, 1685~ 1640,1605,1490,1385, 1370, 1330,1280,1205, 1110,1100,1080,1040, 830,755 TTl (s, 311), 3.28 (s76H),”3.52 (t, J = 4Hz, 4ÏÏ), 4.13 (t, J = 4Hz, 4H), 4.9 (d, J = . 13Hz, 1H), 5.1 (d, J = 13Hz, 1H), 5.38 (s, 1H), 6.7 (br. s, 2H), 7.1-7.6 (m, 5H), 8.85 (s, 1H) 6. táblázat Pld. 'sz. Szerk. képlet kiterm. a számított %-ában olvadás pont °C Üv XMe0Hnm max, 34 çr ■ n02 CoH70CH7CH700C XX rOOCLH, , 7Í N jT 25 ch3 CH20-C0NH-CH3 340 mg 340 mg , 67% 136 136 — 137 236 236 355 35 0" N°2 i-C7H70CH7CH700C X „ COOC-,H, V nY • 5 CH3 A hA CH20-C0NH-CH3 420 mg 85% 120 - 122 235 355 36 no7 kJ c7h,ooc . JJ. cooch7ch7och7 TN if 2 2 3 CH3 AvH A- CH20-CONH-CH3 290 mg 60% 152 - 156 235 355 37 (Y no2 c7h,ooc XX cooch7ch7oc,h7 T N if . -2 2 3 / CH3 AshA CH20-Cf>NH-CH3 360 mg 71% 152- 155,5 236 355 38 ÇT no2 C3H?OCH2CH2OOC JX / COOCH2CH2OC3H7 il n lí CH3 AhA CH20-CCNH-CH3 330 mg 330 mg 65% 119 119 ■ - 120 236 236 355 15
