186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására
1 2 186 583 Pld. IR (KBr): cm'1 sz. 3380, 3290,2970, 1680,' 1640, 1610,1530,1480, 1350, 1275,1200,1120, 34 1100,905,830,780, 760, 715 3370,2980,1680.1640, 1610,1530,1480,1350, 1275, 1205, 1120, 1095, 35 905,830,780,760,710 6. táblázat ('folytatásai H NMR (90 (Hz, DMSO-d6): <5 ppm 0.82 (t, J = 8Hz, 3H), 1.13 (t, J = 8Hz, 3H), 1.48 (m, 2H), 2.35 (s, 3ó), 2.63 (d, d, J = 6Hz, 3H), 3,33 (t, J = 8Hz, 2H), 3.54 (t, J = 5Ht, 2H), 4,07 (q, J = 8Hz, 2H) 4.11 (t, J = 5Hz, 2H), 5.0 (d, J = 13Hz, 1H), 5,09 (s, 1H), 5.13 (d, J = 13Hz, 1H), 7.25 (m, 1H), 7.5-8.3 (m, 4H), 9.10 (s, 1H) 1.06 (d, J " 7Hz, 6H), 1.16 (t, J = 8Hz, 3H), 2.37 (s, 3^, 2.65 (d, J = 6Hz, 3H), 3.56 (m, 1H), 3.60 (t, J = 7Hz, 2H), 4.09 (q, J = 8Ht, 2H), 4,10 (t, J = 7Hz, 2H), 5.03 (d, J = 13Hz, 1H), 5.11 (s, 1H), 5.14 (d, J = 13Hz, 1H), 7.16 (m, 1H), 7.5-8.3 (m, 4H), 9.12 (s, 1H) 3370,3280,2980,1680, 1640, 1610, 1530, 1480, 36^350, 1275, 1205, 1100, 905, 830, 780, 760, _____________715_________ 1.17 (t,J=7Hz,3H), 2.37 (s, 3H), 2.65 (d,J=5Hz,3H), 3.27 (s, 3H), 3.52 (t,J= 5Hz, 2H), 4.10 (q,J=7Hz, 2H), 4.16 (t,J=5Hz, 2H), 5.06 (d,J=14Hz, 1H), 5.1 (s, 1H), 5.14 (t, J=14Hz, 1H),7 18 (m, lH),7.4-8.3 (m,4Hj,9.12(s, 1H) 3380,2980,1680,1640 1610,1530,1485,1355, 37 1280,1205,1100,910, 830,780,760,715 3350, 3300,"296Ö, 2870, 1685,1635,1600,1530, 1480,1350,1275,1250, 38 1200,1130,1100,1015 990,900, 830, 780, 760, 750,710 0.86 (t, J = 7Hz, 3H), 1.2 (t, J = 'Hz, 3H), 1.52 (m, 2H), 2.4 (s, 3H), 2.68 (d, J = 6Hz, 3H), 3.38 (t, J = 7Hz, 2H), 3.58 (t, J = 4Hz,2H),4.1 (q, J = 7Hz, 2H), 4.18 (t, J = 4Hz, 2H), 5.09 (d, J = 1 3Ilz, 1H), 5.13 (s, 1H), 5.18 (d, J = 13Hz, 1H), 7.2 (m, 1H), 7.4—8.4 (m, 4H), 9.12 (s, 1H) '03 '(r;T 7iT/.76rfi.i:5w, 3H), uï (d, j = síi/. 3ii), 3.3 jut 7Ht, 4H), 3.52 (t, J = 4Hz, 411), 4 12 (t, J = 4Hz, 411), 5,0 (d, J = 13Hz, 1H), 5,1 (d, J = 13Hz, 1H), 5.14 (s, 1H), 7.1 (m, 1H), 7.4 - 8.3 (m,4H),9,0 (s, 1H) 6. táblázat (folytatása) Pld. sz. L______ Szerk, képlet kitérni, a számított %-ában Olvadáspont °C UV AMe0Hnm n max 39 rr N02 C9H,00C V . COOCH.CH-OCH, Yn { ~ CH3 A1(A CH20-CONH<g> 330 mg 61% 148- 152 235 355 40 fY N°2 C2H5OCH2CH2OOC COOC2H5 Y nY CH3 A- h A- CH20-C0NH<Q> 370 mg 69% 138 - 142 238 356 41 : Qf no2 C3H?OCH2CH2OOC nYO C00CH2CH20C3H7 Y NX CH3 AhA CH20-C0NH- <2>-Cl 420 mg 420 mg 67% 140 140 - 145 242 242 357 42 ÇT N02 c.ii7och2ch7ooc YY cooch7ch7oc7h7 L YniÍ cD^h^ ch2oconh ci 395 mg 60% 128 - 135 243 355 16
