186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására
1 2 186 583 5. táblázat folytatása Pld. sz. ÍR (KBr): cm'l 1H NMR (90 MHz, DMSO-d6): fi ppm 24 Í480, 3420, 3360, 2950, “ 1710,1690, 1615,1600, 1530, 1490, 1350, 1335, 1250,1200,1125,1080, 930,915, 780,755,720,690 1.16 (t, J = 9Hz, 3H), 2.4 (s, 3H), 3 64 (t, J = 7Hz, 2H), 4.1 (q, J = 9Hz, 2H), 4.25 (t, J = 7Hz, 2H), 5.0 (d, J = 13Hz, 1H), 5.11 (s, 1H), 5.16 (d, J = 13Hz, 1H),6.73 (br. s. 2H), Ó.9-7.5 (m, 5H), 7.4-8.3 (m,4H), 9,16 (s, 1H) .1 25 3500,3360, 2950,1720, 1700,1685,1640,1610, 1530,1485,1350,1330, 1280,1210, 1120,1095, 1085.905.830,780.740.700 1.15 (t, J = %Hz, 3H), 2.37 (s, 3H), 3.63 (t, J = 5Hz, 2H), 4.1 (q, J * 7Ht, 2H), 4.2 (t, J = 5Hz, 2H), 4.52 (s, 2H), 4 98 (d, J = 12Hz, 1H), 5.13 (d, J = 12Hz, 1H), (s, 1H), 6.72 (s, 2H), 7.4 (s, 5H), 7.5-8.3 (m, 4H), 9.11 (s, 1H) 26 3510,3400,3330,2960, 2870,1740,1695,1665, 1525, 1475, 1345, 1325, 1275,1220,1200,1120, 1090,1070,1015,905, 830,785,755,710 0.82 (t, J = 7Hz, 6H), 1.46 (m, 4H), 2.34 (s, 3H), 3.28 (t, J = 7Hz, 4H), 3.5 (t, J = 5Hz, 4H), 4,08 (t, J = 5Hz, 4H), 4.9 (d, J = 12Hz, 1H), 5.8 (d, J = 12Hz, 1H), 5.12 (s, 1H), 6.6 (s, 2H), 7.35 -8.2 (m,4H), 8.95 (s, 1H) i 27 3500,3400, 3000,1690, 1640,1610, 1530,1485, 1350, 1330, 1280,1210, 1110,1095,905,830, 780, 755,720 2.38 (s. 311), 3.3 (s, 6H), 3.53 (t, J = 5Hz, 4tí),'4.12 (t, Í = 5Hz, 4H^, 5.0$ (d, J' = 13Hz, 1H), 5.1 (s, 1H), 5.15 (d,J = 13Hz,9.1 (s,lH) 28 3400,2970,1710, 1690, 1640,1605,1530,1490, 1335,1320,1280, 1205, 1110,1100,1080,860, 830,780,755,710 0.78 (t, J = 7Hz, 3H), 1.08 (t, J = 8Hz, 3H), 1.4 (m, 2H), 2.28 (s, 3H), 23.23 (t, J = 7Hz, 2ó), 3.47 (t, J = 8Hz, 2H), 4.02 (q, J = 8Hz, 2H), 4.05 (t, J = 8Hz, 2H),4.83 (d, J = 13Hz, 1H), 5.0 (d, J = 13Hz, 1K), 5.63 (s, 1H), 6.6 (br. s, 2H), 7.2 -7.9 (m, 4H), 8.86 (s, 1H) 5. táblázat Pld. sz. Szerk. képlet kiterm. a számított %-ában olvadás pont °C UV XMe0Hnm max, 29 fj N02 C3H7OCH2CH2OOC cooc2h5 Y nY ch3 A H CH20-C0NH2 230 mg 47% 117 - 121 233 280 370 30 pv ■ CH3OCH2CH2OOC COOCH2CH2OCH, ¥ N if CH3 AhA CH20-C0NH2 540 mg 65% 162 - 166 235 365 31. flU 0CH3 CH^OCH-CH^OOC cooch0ch0och, ï N T 2 2 3 ch3 /^-H ^ CH20-C0NH2 440 mg 52% — 235 355 32 C\- ci CH.OCH?CH,OOC . COOCH0CH-OCH, 1 í N ¥ 2 2 3 ch3 A-h^ CH20-C0NH2 540 mg 72% 122 — 128 . 237 357 14
