186583. lajstromszámú szabadalom • Eljárás új 2-(kívánt esetben szubsztituált)-amino-karbonil-oxi-alkil-1,4-dihidropiridin származékok előállítására

1

2

186 583

5. táblázat (folytatása)

Pld

U.

IR(KBr): cm'1

*H NMR (90 MHz, DMS0-d6): Ő ppm 1

19

3520,3350,1950, 1700 1645,1610,1520, 1480, 1350.1330,1270,1200, 1120,1100, 1080,905, 830,780,755,720

0.85 (t, J = 8Hz, 3H), 1.18 (t,J = 8Hz, 3H), 1.5 (m, 2H), 2.39 (s, 3H), 3.36 (t,J = (t, J = 8Hz, 2H), 3.57 (t, J = 5Hz, 2H), 4.12 (q, J = 8Hz, 2H),4.15 (t,J = 5Hz, 2H), 5.0 (d, J = 13Hz, 1H), 5.12 (s, 1H), 5.15 (d, J = 13Hz, 1H), 6.68 (br. s. 2H), 7.5 - 8.3 (m, 4H), 9.05 (s, 1H)

20

3520, 33ÓÓ, Í980Í1702, 1685, 1645, 1610, 1525, 1485,1350,1330,1270,

1200.1120.1080.900,

1200.1120.1080.900, 825,780,755,720-----1.06 (d, r=6Hz;6H), 1.16 (t, J “7H£r3ÏÏ)72.37 (s, 3H), 3.55 (m, 1Ü),_3.62

(t, J = 6Hz, 2H), 4.09 (q, J = 7Hz, 2H), 4.12 (t, J = 6Hz, 2H), 4.97 (d, J = 12Hz, 1H), 5.1 (s, 1H), 5.13 (d, J = 12Hz, 1H), 6.65 (br. s. 2H), 7.5-8.3 (m,4H), 9,10 (s, 1H)

21

3480,3380,2990,1690, 1645,1610,1530,1490, 1350, 1275, 1210, 1110, 1095,1080,905,830, 780,755,720

1.16 (t, J = 8Hz, 3H), 2.38 (s, 3H), 3.28 (s, 3H), 3.53 (t, J = 5Hz, 2H),4.08 (q, J = 8Hz, 2H), 4.18 (t, J = 5Hz, 2H), 5.0 (d, J = 13Hz, 1H), 5.11 (s, 1H), 5.13 (d, J = 13Hz, 1H), 6.7 (br. s 2H), 7.5-8.3 (m,4H), 9.07 (s, 1H)

22

15Ô0, $380, Ï98Ô, 171Ô 1680,1640,1600,1525, 1490,1350,1275,1210, 1095,905,830,780, 760,715

0.83 (t, j = 7Hz,~3n], 1.15 (t, J = 7Hz, 3H), 1.5 (m, 2H), 2.37 (s, 3H), 3.35 (t, J ■= 7Hz, 2H), 3.56 (t, J = 3Hz, 2H), 4.08 (q, J = 7Hz, 2H), 4.16 (t, J = 3Hz, 2H), 5.0 (d, J = 13Hz, 1H), 5.1 (s, 1H), 5.15 (d, J = 13Hz, 1H), 6.72 (s, 2H), 7.5-8.3 (m,4H), 9.07 (s, 1H)

23

35ÍÚ,3$6Ö,2940,1705, 1685,1640,1610,1520, 1485,1350,1330,1270, 1200,1120,1100,1080, 1000, 920, 900, 825 780.755.720

1.16 (t, J = 8Hz, 3H), 2.38 (s, 3H), 3.58 (t, J = 5Hz, 2H), 3.98 (d, J = 9Hz, 2H),

4.1 (q, J = 8Hz, 2H), 4.15 (t, J = 5Hz, 2H), 5.08 (d, J = 10Hz, 1H), 5.1 (s, 1H),

5.1 -5.4 (m, 2H), 5.15 (d, J = 10Hz, 1H), 5.6-6.2 (ni, 1H), 6.71 (s, 2H), 7.5- 8.3 (m, 4H)’, 9.11 (s, 1H)

5. táblázat (folytatása)

PkT

sz.

Szerk. képlet

Kiterm. Olvadás UV a számi- pont MeOH tott o maii1111 %-áhan C

24.

ÇT N02

O-0CH7CH900C coocjf

T nT 5

CH^ ^ H ^ CH?0-C0NH?

405 mg 89 235

77% - 93 355

25

fr N°2

c6h5ch2och2ch2ooc y cooc2f5

Xl N jf

CH3 / CH20-C0NH2

300 mg 58,5 236 56 g - 62 355

26.

Cí N°2

C3H7OCH2CH2OOC COOCF*2CH2OC3H7 CH-, AhA CH^O-CCNH,,

410 mg 9i 236 83 % - 99 355

27

O' N°2

CH3OCH2CH2OOC /XX COOCH^CH-OCH, Ti N J Z z J CH3 aHA ch2o-conh2

375 mg 110 236 76% - 115 355

28

űr no2

C-.IFOCHxCIFOOC x , COOCtH^ j|f N|f 25 CH3 /A, cH20-C0NH2

55

320 mg 120 234

65% - 126 340

13

13