184680. lajstromszámú szabadalom • Eljárás az oldalláncban amino-tiazolil csoportot tartalmazó cef-3-ém-4-karbonsav-származékok előállítására

184 680

R,

Rj

Ra

Ra

X

A-H

benzil-H-H-S-ch2-o-c-ch3

O-H

benzil

—H-H-S-ch2-s-c-ch3

O-H

benzil

—H-H

—S(387)-H

benzil

(422)-H-s(264)-H

p-nitro-benzil

—H-H-s-ch2—o-c-ch3

O

N-N-H

p-nitro-benzil-H

O ch3-H-s-ch2-s----ch3

s-H

p-nitro-benzil-ch2o-c-c-ch3

1

ch3-H-s-ch2-s-c-ch3

8

O

—H

p-klór-benzil-H-H-s-ch2-o-c-ch3

O

—H

p-klór-benzil-H-H-s(2)-H

p-metil-benzil-H-H-S—-ch2-o-c-ch3

O

—H

m-metil-benzil-H-H-S-ch2-o-c-ch3

O

—H

(439)-H-H-s-X

U

1

o—o

!

0

1

X

U

1-H

(439)-H-H-s(388)-H

(440)-H-H-s-ch2-o-c-ch3

1

0-H

(440)-ch2-cooh-H-s-ch2-o-c-ch3

0-H

(440)-H-H-s-ch2-s-c-ch3

1

o-H

(441)-H-H-s-ch2-o-c-ch3

1

0-H

(442)-H-H-s-ch2-o-c— ch3 0-H

(443)-H-H-s-ch2-o-c-ch3

1

o-H

(444)-H-H-s-ch2-o-c-ch3

1

o-H

(445)-H-H-s-ch2-o-c-ch3

o

—H

(446)-H-H-s-ch2-o-c-ch3

o

CI—CHi—C— 1

O

p-klór-benzil-H

—H-s-ch2-o—c— ch3 o

Cl—CH2—C— 1 O

Cl—CH*—C —

p-nitro-benzil-ch2-o-c _ch3 1

O-H-s—

1

0 X

1

0

1

0-0

1

o

s

O

p-metil-benzil-H

—H-s—ch,— s—c—ch3 o

SHS—O—CHi—C — 1

O

benzil-H

—H-s—

1

0 X

1

0

1

0-0

1

o

X

SH,—C—CHi—C — 1

p-klór-benzil-H-H

—s(389)

O

20