184680. lajstromszámú szabadalom • Eljárás az oldalláncban amino-tiazolil csoportot tartalmazó cef-3-ém-4-karbonsav-származékok előállítására

184 680

*

R.

r2

r3

R.

X

A

c6h.-o-ch2-c-II

0

(439)

—K

—H-S-ch2-o-c-ch3

H

0

C«HS—O—CHa—C—

(441)

—K-H

—S-ch2-o-c-ch3

1

o

O

c6

h5-o-ch2-c-1

(446)

—H-H-S-ch2-o-c-ch3

o

x<-h3

o

(Cs

H5)3-C(440)-Q^c:h3-H-s-ch2-o-c-ch3

ch3

0

(C6H3)3-C

p-metil-benzil

—H-H-s-ch2-s-c-ch3

II

o

(C6Hs)3-C(444)-H

—H-s-ch2-s-c-ch3

o-H

(440)

(421)

—H-s—ch2—o—c— ch3 II

0

—H

p-klór-benzil-ch-co2ch3-H-s-ch2-o-c-ch3

1

och3

o-H

(439)-ch2-cooh-H-s-ch2-o-c-ch3

o-H

p-metil-benzil

—CHí—CCI

—H-s-ch2-o-c-ch3

o

—H

(442)-ch2-cooh-H-s-ch2-o-c-ch3

II

0

—H

(443)-ch2- o -no2-H-s-ch2-o-c-ch3

0

^ch

3-H

(446)-c<-CH3

ch3

—H-s-ch2-o-c-ch3

II

o

ch3

—H

(445)

th, n r r ^tt

—H

s

PH. n C PH.

^ h ^

o CHj

ő

/CH3-H-ch3-c^-ch3-H

—s—

(390)

nch3

C1-CH2-C-ch2-ch=ch2-H-H-s-390)

O-H-ch2-cooh-H

—H-s(391)

ch3

*

/

—H-c-ch2-o-c-ch3-H-s—

(391)

\

í

ch3

o-H-H-H

—H-s(391)-H-CH2 - COOCjHj-ch2 —COOC2Hs-H-s(391)-H

p-nitro-benzil-H

—H-s—

(392)

r-ch2-ch3-CH-COOH-H-H-H —H

c6

h5-ch3-ch3--s(jyz)

(393)

1

C2Hs

—H-ch3-ch2-o-c-c6hs

II

o-H-s(393)

Br—CH2—C —-ch2-ch2-ch2-ch3-H-H-s(394)

O

ch3

/-H

(442)-CH-H-s(395)

\

ch3

21