172517. lajstromszámú szabadalom • Eljárás 6-dezoxi-tetraciklin származékok előállítására
11 172517 12 Nyomás Savas sóx Oldószer501 T C° Idő (óra) (at) R, r2 r3 HC1 NMP 70 28 0,95-c6h5-c6hs-c6h5 HC1 NMP 70 18 3,4 4-ClC6H4-4-ClC6H4-4—C1C6H4— HC1 NMP 70 18 13,6-C6Hs —C2 Hs HC1 NMP 80 20 13,6-c6h5 ~C6HS-H HC1 NMP 75 18 3,4 2-ClC6H4-2-ClC6H4-2-ClC6H4-HC1 NMP 70 18 3,4 3—C1C6H4-3-ClC6H4-3-ClC6H4-HC1 NMP 70 18 3,4 4—Me2NC6H4-4-Me2NC6H4-4-Me2NC6H4-HC1 NMP 70 18 6,8 4—Et2NC6H4— 4-Et2 NC6H4-4—Et2NC6H4-HC1 NMP 70 18 5,1 ~c6hs-c« h5 4—ClCé H4 — HC1 CHjOH 70 18 5,1-C6Hs 4-BrC6H4-HC1 NMP 75 20 4,4-CeHs-C6 Hs 4-Me2NC5H4-HC1 NMP 70 18 68 4-tőül-4-tolil-4-tolil-PTS NMP 70 20 13,6 4—tőül-4-tolil-ch3 PTS NMP 80 18 6,8-c6hs 4—tolil—-ch3 PTS NMP 80 18 6,8-c6hs 4-BrC6H4~ 4-Me2NC6H4-PTS NMP 80 18 6,8 4—tolil-4-tolil-4-MeOC6H4 -HC1 CH3OH 80 18 6,8 4—C1C6H4-4-ClC6H4-4-ClC6H4-citromsav CH3OH 75 24 3,4-c6hs-C6Hs-c6h5 borkősav NMP 75 24 3,4 2—tolil— 2—tolil— 2—tolil— PTS THF 70 24 3,4-C*HS —C6Hs-c6h5 PTS THF 60 36 6,8-c6h5 4-tolil-C2Hs PTS C2H5OH 50 18 13,6-c6h5 4-MeOCé H4 -n—C4 H9 — HBr NMP 80 16 6,8 4-C1C«H4-4-ClC6H4-4-ClC6H4-HC1 dioxán 80 15 34-c«h5 —CéHs-C6Hs PTS NMP 50 20 1 136-c6h5-c6h5 PTS aoeton 80 18 68-c6h5-CsHs-c6hs PTS glime 75 24 68-c«h5-c6h5 "^«Hs 60 XPTS = p-toluolszulfonsav, THF = tetrahidrofurán, NMP = N-metil-2-pirrolidon, ágiimé = 2'inetoxietanol, 6
