150834. lajstromszámú szabadalom • Eljárás peptidek előállítására
F : C° [*] D 3 a N«—Palm—(N e —Z)—L—Lys—(N£ —ZV-L—Lys—OC2H 5 NcL_Palm —L—Lys—L—Lys—OC2H 5 • 2HC1 110—113 (Et/Aq) 242—246 (Et) —23° (c=3, Aq) b Na —Palm—L—Lys—L—Lys—OC2H5 • 2H3P0 4 165 (Ac/Aq) —20° (c = 3, Aq) c Na —Palm—<N E — Z)—D—Lys—(N£ — Z)—D—Lys—OC2H 5 N a —Palm—D—Lys—D—Lys—OC2H5 • 2HC1 110—113 (Et) 242—246 (Et) +23° (c = 3, Aq) d Na — Palm—(N£ —Z)—DL—Lys—(N £ —Z)—DL—Lys—OC2H 5 N a —Palm—DL—Lys—DL—Lys—OC2H 5 • 2HC1 93—109 (Et) 210—220 (Et) e N a —stearoil—(N £ — Z)—L—Lys—(N£ —Z)—L—Lys—OC2H 5 N a —stearoil—L—Lys—L—Lys—OC2H 5 • 2HC1 106—108 (Et/Aq) 235—240 (Et) -21° (c = 3, Aq) f Na —Palm—(N a — Z)—L— Orn—(Na —Z)—L—Orn—OCH3 N a —Palm—L—Orn—L—Orn—OCH3 • 2HC1 121—124 (E) 230—233 (Me/Ac) —1,9° (c=l, DMF) —12,2° (c=2, Me) g N a —Palm—(Na —Z)—L—Orn—L—Nitroarg—OCH3 Na —Palm—L—Orn—L—Arg—OCH3 • 2HC1 135—139 (E) 217—220 (Me/Ac) —2,5° (c=l, DMF) —5,2= (c=2. Me) h N a —Lauroil—(N£ — Z)—L—Lys—(N£ —Z)—L—Lys—OCH3 N a —Lauroil—L—Lys—L—Lys—OCH3 • 2HC1 137—139 (Me/Ac) 212—214 (Me/Ac) —11,6° (c = 2, Me) —20,0° (c = 2. Me) i N a —Palm—(N v — z)—L— Dab—(NT-Z)—L—Dab—OCH3 Na — Palm—(NT —Z)—L—Dab—(N f—Z)—L—Dab—NHNH2 Na —Palm—L—Dab—L—Dab—NHNH2 -2HC1 119—121 (E/P) 183—184 (DMF/Ac) 134 (Me/Et) —13,8° (c = 2, DMF) k Na , N£—Di—Z—L—Lys—(N £ —Palm)—L—Lys—OCH3 H—L Lys—(N £ —Palm)—L—Lys—OCH3 • 2HC1 151—153 (Me/Aq) 170 (Me/Et) i i N a , N £ — Di—Z—L—Lys—(N£ —Palm)—L—Lys—NHNH2 H—L—Lys—(N£ — Palm)—L—Lys—NHNH2 • HBr 178—180 (Aq) 194—195 (Et/Aet) m Na —kaprinoil—(N £ —Z)—L—Lys—(N£ —Z)—L—Lys—OCH3 N a _kaprinoil—L—Lys—L—Lys—OCH3 • 2HC1 130—132 (Me/Aet) 206—211 (Me/Aet) —11,5° (c = 2, Me) —19,9° (c = 2, Me) n Na —Palm—(N £ —Z)—L—Lys—L—Ser—OCH3 N a —Palm—L—Lys—L—Ser—OCH3 • 2HC1 125—127 (Me) 139 (Aq/Ac) —8,2° (c = 2, Aq) 0 N a —Palm—(N £ — Z)—L—Lys—L—Leu—OCH3 N a —Palm—L—Lys—L—Leu—OCH3 86— 88 (E) 181—185 (Aq) —13,6° (c = 2, DMF) —33,2° (c = l, Aq) P Na —Palm—(N a —Z)—L—Lys—L—Tyr—OCH3 N a —Palm—L—Lys—L—Tyr—OCH3 105—108 (E) 159—161 (Ne/E) —1° (c = 2, DMF) — 42,6° (c=l, Aq)
