Dr. Murai Éva szerk.: Parasitologia Hungarica 14. (Budapest, 1982)
Parasit, hung. 14. 1981-1982. Effective albendazole treatment of laboratory mice infested with Aspiculuris tetraptera Ferenc GÀL Miklós JANISCH — Zsuzsanna SOMFAI-RELLE National Oncological Institute, Research Institute of Oncopathology, Budapest, Hungary — University of Veterinary Sciences, Department of Parasitology, Budapest, Hungary "Effective albendazole treatment of laboratory mice infested with Aspiculuris tetraptera"Gál, F. - Janisch, M. - Somfai-Relle, Zs. - Parasit.hung. 14: 45-49, 1981-82. ABSTRACT. An attempt to treat with Mebenvet 0 ^a natural infestation of mouse stock with Aspiculuris tetraptera was ineffective. Albendazole, another benzimidazole derivate, not yet marketed, was kindly rendered at our disposal by the CHINOIN Pharmaceutical and Chemical Works Ltd., Budapest, Hungary. Based on acute toxicity studies and coprological control examinations, the mouse stock treated with 200 mg/kg albendazole for 2 days was freed from worms and ova. INTRODUCTION Mice derived exclusively from own breeding stock are used for experiments at the National Oncological Institute. Recent histologicalexamination of their organs for oncopathological purposes have, however, shown the presence of worms in the colon of the mice. Since infestation may disturb the experiments we asked the Department of Parasitology, Veterinary University, Budapest, to examine our mouse stock. Gy Firstly Mebenvet -containing mebendazole - then albendazole was applied to medicate infestation. Albendazole (another benzimidazole derivate, not yet marketed) was kindly rendered at our disposal by the CHINOIN Pharmaceutical and Chemical Works Ltd., Budapest. Efficacy of albendazole on entoparasites has been confirmed in various domestic animals (1, 2, 3, 5, 6, 7), it has, however, not been applied so far to small laboratory rodents . MATERIALSAND METHODS Animals . The mouse strains currently bred at the National Oncological Institute are as follows: Hriop: Swiss outbred, A/Sn/Hriop, BALB/c/Hriop, C57Bl/6/Hriop, DBA/2/Hriop inbred and BDFl/Hriop hybrid. For bedding sterile shavings changed three times a week are used. Animals are provided with standard diet (LATI, Gödöllő, Hungary) and tap water ad libidum. Before consumption food is pasteurized for 3 hours at 80°C. Conditions of animal production and experimentation are completely identical. Detection of Aspiculuris tetraptera (Nitzsch, 1821) and its ova . Thirty five faeces samples per mouse strain were tested in order to identify the helminth species of parasite found in the colon of the mice and to determine whether the whole mouse stock was infested.
