Hidrológiai Közlöny, 2015 (95. évfolyam)
2015 / 5-6. különszám - LVI. Hidrobiológus Napok előadásai
99 the cyanobacterium Cylindrospermopsis raciborskii from Portuguese freshwaters Ecotoxicol Env Safety 55: 243-250 Singh S, Kate BN, Banerjee UC. 2005. Bioactive compounds from Cyanobacteria and Microalgae: an Overwiev. Crit Rev Biotechnol. 25:73-95. Sinha R, Pearson LA, Davis TW, Burford MA, Orr PT, Neilan BA. 2012. Increased incidence of Cylindrospermopsis raciborskii in temperate zones - Is climate change responsible? Water Res 46:1408-1419. Tidgewell K, Benjamin RC, Gerwick WH. 2010. Comprehensive Natural Products II. Chemistry and Biology. Mander L and Lui HW. editors. Oxford: Elsevier, p 141-188. Törökné AK, Vasdinnyei R, Asztalos BM. 2007. A rapid microbiotest for the detection of cyanobacterial toxins. Env Toxicol 22:64-68. Vasas G, Surányi G, Máthé C, M-Hamvas M, Borbély G. 2010. Investigation of toxin content in Cylindrospermopsis raciborski (Wofos- zynska) Seenaya and Subba Raju and Aphanizomenon ovalisporum (Forti) strains isolated from shallow lakes of Hungary. Acta Biol Hung 61:218-225 Vehovszky Agnes, Ács András, Kovács W. Attila, Szabó Henriette, Győri János, Gácsi Mariann, Farkas Anna 2011. Balatonból izolált cianobaktériumok vizes kivonatainak bioaktív hatásai - összehasonlító vizsgálatok Hidrológiai Közlöny 91. 110-112. Vehovszky A, Kovács AW, Szabó H, Győri J, Farkas A. 2012. Neurotoxic effects evoked by cyanobacterial extracts suggest multiple receptors involved in electrophysiological responses of molluscan (CNS, heart) models. Acta Biol. Hung 63:160-170. Algavirágzás és halpusztulás - neurotoxikus (?) Cylindrospermopsis raciborskii törzsek Magyarországon AgnesVehovszky, Attila W. Kovács, Anna Farkas, János Győri, Gábor Vasas Abstract: Keywords: Early November, 2012, a rapid cyanobacterial bloom of Cylindrospermopsis raciborskii (Woloszynska) Seenayya et Subba Raju (Noctocales, Cyanophycae) was detected in the Fancsika pond (East Hungary near Debrecen), characterized by a strong discoloration of water and a substantial fish mortality. Our previous results demonstrated the neurotoxic effects of other C. raciborskii isolates (collected from the Balaton region, Hungary during natural bloom in 1995), therefore, we could not exclude the involvement of a kind intoxication responsible for the mass fish kill in the Fancsika pond. To test the potential toxic effects electrophysiological experiments were carried out on identified neurons in the CNS of Helix pomatia. The neuronal effects of the Fancsika bloom sample (FBS), the laboratory isolate of C. raciborskii from the pond (FLI) and the reference samples of C. raciborskii ACT 9505 (isolated from Balaton), suggested a common target, the neuronal acetylcholine receptor (AChR). Pharmacological tests demostrated a dose-dependent blocking effects of cyanobacterial extracts, functionally similar to the already identified cholinergic cyanotoxins (anatoxin-a and homoanatoxin-a), although analytical assays excluded the presence of any of them in the samples tested. We conclude, therefore, that a new chemotype of C. raciborskii strain which produce some cholinergic, but structurally not yet identified neuroactive substances is likely distributed in this region of Europe including Hungary. Cylindrospermopsis, Fancsika, fish kill, neurotoxin, anatoxin-a, Helix, acetylcholine
