Fogorvosi szemle, 2005 (98. évfolyam, 1-6. szám)
2005-10-01 / 5. szám
204 FOGORVOSI SZEMLE ■ 98. évf. 5. sz. 2005. 21. McGaw T, Lam S, Coates J: Cyclosporin-induced gingival overgrowth: Correlation with dental playue score, gingivitis score, and cyclosporin levels in serum and salvia. Oral Surg. Oral Med. Oral Pathol. 1987;64:293-297. 22. N1SIKAWA sj, Tada h, Hamasaki a, et al: Nifedipine-induced gingiva hyperplasia: A clinical and in vitro study. J Periodontol 1991 ; 62: 30-35. 23. Nuki k, Cooper sh: The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin sodium in cats. J Periodontol 1972;7: 102-110. 24. Oettinger-barak O, Machtei EE, Peled M, Barak S, Naaj IA, Läufer D: Cyclosporine A-induced gingival hyperplasia pemphigus vulgaris: Literatura review and report of a case. J Periodontol2000; 71 : 650-656. 25.Oyer PE, Stinson EB, Jamieson SW, ET AL.: Cyclosporin A in cardiac allografting: A preliminary experience. Transpl Proc 1983; 15: 1247-1252. 26. Palestine AG, Nussenblatt RB, Chan CC: Side Effects of Systemic Cyclosporine in Patients Not Undergoing Transplantaion. The American Journal of Medicine 1984; 77: 652-656. 27. Pillati GL, Sampaio JEC: The influence of chlorhexidine on the severity of cyclosporin A-induced gingival overqrowth. J Periodontol 1997; 68:900-904. 28-Pilloni A, Camargo PM, Carere M, Carranza FA, Jr: Surgical Treatment of Cyclopsorine A- and Nifedipine-Induced Gingival Enlargement: Gingivectomy Versus Periodontal Flap. J Periodontol 1998; 67: 791-797. 29.Rateitshank-Pluss EM, FIefti A, Lörtscher R, Thiel G: Initial observation that cyclosporin-A induces gingival enlargement in man. Journal of Clinical Periodontology ’\983\ 10: 237-246. 30.Seymour RA, Smith DG, Rogers SR: The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. J Clin Periodontol 1987; 14: 610-613. 31. Saravia ME, Svirsky JA, Friedman R: Chlorhexidine as an oral hygiene adjunct for cyclosporin-induced qinqival hyperplasia. J Dent Child990', 57: 366-370. 32.Seymour RA Heasmann PA: Drugs and the periodontium. J Clin Periodontol 1988; 15:1-16. 33. Seymour RA, Smith DG:The effect of a plaque control programme on the incidence and severity of cyclosorin-induced gingival changes. J Clin Periodontol 1991 ; 18:107-110. 34.S0MACARRERA ML, Hernandez G, Acero J, Moskow BS: Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994; 65: 671-675. 35-SooriyamoorthyM, Gower DB, Ely BM: Androgen metabolism in gingival hyperplasia induced by nifedipine and cyclosporin. J Periodontol Res 1990; 25: 25-30. 36. Thomason JM, Seymour RA, Ellis JS, Kelly PJ, Parry G, Dark J, Idle JR: Iatrogenic Gingival Overgrowth in Cardiac Transplantation. J Periodontol 1995; 66: 742-746. 37. Thomason JM, Seymour RA, Rice N: The prevalance and severity of cyclosporin and nifedipine-induced gingival overgrowth. J Clin Periodontol 1993; 20: 37-40. 38-Tyldesley WR, Rotter E: Gingival Hyperplasia Induced by Cyclosporin-A. BrDent J1984; 157: 305. 39. Ziskin de, Stowe lr, Zagarelli ev: Dillantin hyperplastic gingivitis. Am J Orthod-\941 ; 27: 350. E. Benedek, I. Gera, T. Keglevich: Organ Transplant Patients’ Complex Periodontal Treatment The number of organ transplant patients has increased in recent years. The Cyclosporin-A (CsA) has been used at least for 20 years to control graft rejections. As many organ transplant patients also take Ca channel blocking medication this might potentiate the CsA associated gingival hyperplasia. The outcome of the comprehensive periodontal treatment was evaluated in 14 kidney and liver transplant patients. If gingival overgrowth showed no marked reduction after thorough professional supra and subgingival plaque control either gingivectomy or flap surgery were indicated. The average age of the organ transplant patients was 38 years. 10 was man and 4 female. The daily dose of CsA ranged between 150-200 mg, and each patient took also Ca channel blocking drugs, 5-20mg/day. S/RP alone was successful in two cases. Gingivectomy was performed in 10 cases and flap operation was indicated in two cases. Among patients with high compliance and excellent individual oral hygiene no recurrence occurred, while two patients with very low level of oral hygiene showed immediate gingival overgrowth after surgery. It is supposed that dental plaque is an important contributing factor in the development of drug induced gingival overgrowth and meticulous plaque control should be one of the most important treatment modalities in controlling druginduced gingival changes. Key words: Drug side effects, organ transplant patients, gingival enlargement
