Fogorvosi szemle, 2002 (95. évfolyam, 1-6. szám)
2002-02-01 / 1. szám
20 FOGORVOSI SZEMLE 95. évf. 1. sz. 2002. 48. Schincaglia GAP, Forniti F, Cavallini R: Cyolosporin-A increases type I procollagen production and mRNA level in human gingival fibroblasts in vitro. J Oral Pathol Med2:181, 1992. 49. Seymour RA, Heasman PA: Drugs and the periodontium J Clin Periodontol 1988; 15: 1-16. 50. Seymour RA, Jacobs DJ: Cyclosporin and the gingival tissue. J Clin Periodontol 1992; 19: 1-11. 51. Seymour RA, Smith DG, Rogers SR: The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. J Clin Periodontol 1987; 14: 610-613. 52. Seymour RA, Smith DG: The effect of a plaque control program on the incidence and severity of cyclosporin-induced gingival changes. J Clin Periodontol 1991 ; 18: 107-116. 53. Somacarrera ML, PIernandez G, Acero J, Moskow BS: Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study. J Periodontol 1994; 65: 671-675. 54. Stewart PJ, Stern PH: Cyclosporine: correlation of immunosuppressive activity and inhibition of bone resorption. Calcif Tissue Int 1989; 45: 222-226. 55. Williamson MS, Miller EK, Plemos J, Rees T, Iacopino AM: Cyclosporine A upregulates interleukin-6 gene expression in human gingiva: Possible mechanism for gingival overgrowth. J Periodontol 1994; 65: 895-903. 56. Wysocki GP, Gretzinger ha, Laupacis A, Ulan RA, Stiller CR: Fibrous hyperplasia of the gingiva: A side effect of cyclosporin- A therapy. Oral Surg Oral Med Oral Path 1983; 55: 274-278. 57. Ziskin DE, Stowe LR, Zagarelli EV: Dilantin hyperplastic gingivitis. Am J Orthod 1941 ; 27: 350. Keglevich T, Windisch P, Gera I: Control of Periodontitis combined with Cyclosporin-Induced Gingival Overgrowth by Regular Professional Mechanical Debridement and a Maintenance Program (A Case Report) A clinical case of a middle-aged kidney transplanted woman is presented. The woman has been taking Cyclosporin-A for over 13 years and has had advanced periodontitis and severe gingival swellings and gingival inflammation. The kidney transplant patient was treated and followed up for approx, four years. The treatment protocol included very thorough mechanical scaling and root planing, oral hygienic instructions and the regular professional maintenance program resulted in complete remission of the gingival overgrowth and stabilization of the periodontal condition. The gingival and periodontal conditions showed a continuing improvement over the time despite of the continuous CSA administration. Key words: kidney transplantation, gingival overgrowth, Cyclosporin-A side effects, mechanical debridement, periodontal maintenance
