Fogorvosi szemle, 1991 (84. évfolyam, 1-12. szám)

1991-04-01 / 4. szám

az atropinelőkezelés hatástalannak bizonyult. Christensen [3] a NAI rostkötegében kimutatott ugyan vegetatív idegágakat, de ezek szimpatikus természetűnek bizonyultak. Fentiek alapján úgy látszik tehát, hogy a szájnyálkahártyában kísérletesen létrehozott neurogén inflammáció hatásmechanizmusában a kolinerg szabályozás nem játszik szerepet.

IRODALOM: 1. Brodin, E., Gazelius, B., Lundberg, J. M., Olgart, L.: Substance P in trigeminal nerve endings: occurence and release. Acta Physiol. Scand. Ill, 501, 1981. — 2. Brodin, E., Nilsson, G.: Concentration of substance P-like immunoreactivity (SPLI) in tissues of dog, rat and mouse. Acta Physiol. Scand. 112, 305, 1981. — 3. Christensen, K.: Sympathetic nerve fibers in the alveolar nerves and nerves of the dental pulp. J. Dent. Res. 19, 227, 1940. — 4. Couture, R., Cuello, A. G.: Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat. J. Physiol. 346, 273, 1984. — 5. Couture, R., Cuello, A. C., Henry, J. L.: Trigeminal antidromic vasodilatation and plasma extravasation in the rat: effects of sensory, autonomic and motor denervation. Brain Res. 346, 108, 1985. — 6. Fazekas, A., Vindisch, К., Pósch, E., Győrfi, A.: Experimentally induced neurogenic inflammation in the rat oral mucosa. J. Periodont. Res. 25, 276, 1990. — 7. Gämse, R., et al.: Several mediators appear to interact in neurogenic inflammation. Acta Phyisol. Hung. 69, 343, 1987. — 8. Gazelius, B., Olgart, L.: Vasodilatation in the dental pulp produced by electrical stimulation of the inferior alveolar nerve in the cat. Acta Physiol. Scand. 108, 181, 1980. — 9. Grace, G. C., et al.: Endothelium and the vasodilatator action of rat calcitonin gene-related peptide (CGRP). Br. J. Pharmacol. 91, 729, 1987. — 10. Lawson, S. N.: The morphological consequences of neonatal treatment with capsaicin on primary afferent neurones in adult rats. Acta Physiol. Hung. 69, 315, 1987. — 11. Lembeck, F., Holzer, P.: Substance P as neurogenic mediator of antidromic vasodilatation and neurogenic plasma extravasation. Naunyn-Schmiedeberg’s Arch. Pharmacol. 310, 175, 1979. — 12. Lundberg, J. ill., Saria, A.: Capsaicin-sensitive vagal neurons involved in control of vascular permeability in rat trachea. Acta Physiol. Scand. 115, 521, 1982. -— 13. Lundblad, L., Saria, A., Lundberg, J. ill., Anggard, A.: Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicinsensitive trigeminal neurons. Acta Otolaryngol. 96, 479, 1983. — 14. McMillian, M. K., Talamo, B. R.: Lack of desensitization neurokinin A due to partial agonist property of this peptide at parotid substance P receptors. Brain Res. 480, 330, 1989. — 15. Rosell, »$'., et al.: Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist. Acta Physiol. Scand. Ill, 381, 1981. -— 16. Saria, A., Hua, X., Skofitsch, G., Lundberg, J. M.: Inhibition of compound 48/80-induced vascular protein leakage by pretreatment with capsaicin and substance P antagonist. Naunyn- Schmiedeberg’s Arch. Pharmacol. 328, 9, 1984. — 17. Szolcsányi, J.: Antidromic vasodilatation and neurogenic inflammation. Agents and Actions 23, 4, 1988.

Győrfi A. Dr., Fazekas Á. Dr., Pósch E. Dr., Irmes F. Dr., Rosivall L. Dr.: Role of the histamin in the nemigen inflammation of rat-oral osft tissue

The effect mechanism of neurogen inflammation incited by local capsaicin irritation was examined by the authors in the oral soft tissue of rats subsequent to antihistamin pretreatment. Furthermore, with the aid of muscarin blocking receptor also the parasympathetic component of the vasodilatation was examined.

On basis of their results it was established that the vein-wall-permeability and microcircular changes observed in the course of the neurogen inflammation of the oral soft tissue partly expanded by the histamin through the H,-receptors. The H2-receptors as well as the parasympathetic fibers do not become activated in the process.

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