Fogorvosi szemle, 1995 (88. évfolyam, 1-12. szám)

1995-07-01 / 7. szám

IRODALOM: 1. Adler-Hradeczky C., Kelentey В.: Penicillin kiválasztódása és bomlása a nyálban. Fogorv. Szle. 55, 417, 1962. — 2. Bender, I. В., Pressman, R. S., Tashman, S. G.: Studies on excretion of antibiotics in human saliva. Penicillin and Streptomycin. J. Am. Dent. Assoc. 46, 164, 1953. — 3. Cannel, HKerawala, C., Shefto, A. M., Maskell, J. P.. Seymour, .4.. Sun, Z-M.. Williams, J. D.: Failure of two macrolide antibiotics to prevent post-extraction bacteraemia. Br. Dent. J. 171, 170, 1991. — 4. Csáky, T. Z., Barnes, B. A.: Cutting’s Handbook of Pharmacology. Appleton-Centrury-Crofts, Norwalk, 1984. 27—29. — 5. Ehrenfeld, MClindamycin in the Treatment of Dental Infections. Zambrano, D. (ed.): Clindamycin in the Treatment of Human Infections. Upjohn, Kalamazoo, 1992. 10—1. — 6. Vorth, W., Henschler, D., Rummel, W.: Pharmakologie und Toxikologie. Bibliographisches Institut, Zürich, 1984. 573—577. — 7. Gräber, HAz antibiotikumkezelés gyakorlata. Medicina, Budapest, 1993. 96—102, 113—115. — 8. Heimdahl, A., Von Konow, L., Nord, C. E.: Isolation of ß-lactamase-producing Bacteroides strains associated with clinical failures with penicillin treatment of human orofacial infections. Arch. Oral Biol. 25, 689, 1980. — 9. Hejzlar, M., Paroubek, MVacek, V., iSilanová, J.: Fifteen Years of Experience with Lincomycin Antibiotics. Periti, P., Grassi, G. G. (ed.) Current Chemotherapy and Immunotherapy. American Society for Microbiology, Washington, 1982. 920, Vol. II. — 10. Inouye,

S., Niida, TDiscovery and Development of Midecamycin. Periti, P., Grassi, G. G. (ed.): Current Chemotherapy and Immunotherapy. American Society for Microbiology, Washington, 1982. 886, Vol. II. — 11. Kannangara, D. W., Thadepalli, II., McQuirter, J. L.: Bacteriology and treatment of dental infections. Oral Surg. 50, 103, 1980. — 12. Ifj. Kelentey,

B. : Cefalosporinok kiválasztódása a nyálban. Fogorv. Szle. 76, 213, 1983. — 13. Kelentey, B. A., Kelentey, B. J.: Cefsulodin és Moxalactam kiválasztódása a nyálban. Fogorv. Szle. 80, 183, 1987. — 14. Ifj. Kelentey, B. A., Kelentey, B. J.: Az aminoglikozidok nyálban történő kiválasztódásának vizsgálata. Fogorv. Szle. 84, 313, 1991. — 15. Morse, D. R., Fürst, M. L., Lefkowitz, R. D., D’Angelo, D., Esposito, J. VA comparison of erythromycin and Cefadroxil in the prevention of flare-ups from asymptomatic teeth with pulpal necrosis and associated periapical pathosis. Oral Surg., Oral Med., Oral Pathol. 69, 619, 1990. — 16. Newman, M. G., Kornman, K. 8.: Antibiotic/Antimicrobial Use in Dental Practice. Quintessence, Chicago, 1990, 76—79, 86—87, 153—154, 164, 205. — 17. Panichi, G.: Antibiotic Treatment of Anaerobic Infections. Scand. J. Infect. Dis. Suppl. 62, 47, 1989. — 18. Sanford, J. P.: Az antibiotikus kezelés irányelvei 1991. Petit Kft., Budapest. 1991. 72—73, 124. — 19. Simon,

C. , Stille, W., Münnich, D.: Korszerű antibiotikumterápia. Springer Hungarica Kiadó Kft., Budapest, 1991. 138—159. — 20. Sutter, V. L., Finegold, S. M.. Susceptibility of Anaerobic Bacteria to 23 Antimicrobial Agents. Antimicrobial Agents and Chemotherapy. 10, 736, 1976. — 21. Tierney, L. M., McPhee, S. J., Papadakis, M. A., Schroeder, S. A.: Korszerű orvosi diagnosztika és terápia 1993. Melania Kft., Budapest 1993. 1195, 1206. — 22. Uri J Dermatophytonok az antibiotikum-kutatásban. Kandidátusi értekezés, Budapest, 1956.

Dr. Kelentey, B. Á., fdr. Kelentey, B. J.: The excretion of erythromycin, clindamycin and lincomycin into saliva

In rabbit experiments (n=10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration.

Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.

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