Szemészet, 2019 (156. évfolyam, 1-4. szám)

2019-09-01 / 3. szám

Primary vitreoretinal lymphoma

felfedezésre, míg idegrendszeri érintettséggel nem jár. A PIOL- tünetek kialakulása és a definitiv

diagnózis meghozatala közötti késés 4-40 hónap (18). Az uveitis

kivizsgálása során talált pozitív teszteredmények sok esetben félrevihetik, illetve késleltethetik a végső diagnózis felállítást. A primer intraocularis

lymphoma di

agnosztikai és terápiás kihívás. Csak a szemészek, az onkológusok, az idegsebészek, a radiológusok, a radioterapeuták és a patológusok interdiszciplináris együttműködésével lehet megfelelő diagnózist felállítani és a beteget kezelni.

Irodalom

1. Cantu

CA,

Green

CL,

Cummings

TJ,

Liu

B,

Dash

RC.

Flow

cytometry immunophenotyping of

vitreous specimens does not contribute to diagnosis of lymphoma without supporting morphologic features. Diagn Cytopathol 2019; 47(4): 275-281.

2. Chan

CC, Rubenstein JL, Coupland SE, et al. Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist 2011; 16: 1589-1599.

3. Cockerham

GC, Hidayat AA, Bijwaard KE, Sheng ZM. Re-evaluation of “reactive lymphoid hyperplasia of the uvea": an immunohistochemical and molecular analysis of 10 cases. Ophthalmology 2000; 107(1): 151-8.

4. van

Dongen JJ, Langerak AW, Brüggemann

M,

Evans PA, Hummel M, Lavender FL, Delabesse E, Davi E Schuuring E, Garcia-Sanz R, van Krieken JH, Droese J, González

D,

Bastard C, White HE, Spaargaren M, Gonzalez M, Parreira A, Smith JL, Morgan GJ, Kneba M, Macintyre EA. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BI0MED-2 Concerted Action BMH4-CT98-3936. Leukemia 2003; 17(12): 2257-317.

5. Dunn

JP Interleukinsin the Diagnosis of Intraocular Lymphoma: Do We Still Need Histologic Confirmation? Retina 2018; 38(4): 847-649.

6. Fardeau

C, Lee CR Merle-Béral

H,

Cassoux N, Bodaghi B, Davi E Lehoang P Retinal fluorescein, indocyanine green angiography, and optic coherence tomography in non-Hodgkin primary intraocular lymphoma. Am J Ophthalmol 2009; 147(5): 886-94.

7. Ferreri

AJM. Therapy of primary CNS lymphoma: role of intensity, radiation, and novel agents. Hematology Am Soc Hematol Educ Program 2017; 565-577.

8. Finger

PT, Papp C, Latkany R Kurli M, lacob CE. Anterior chamber paracentesis cytology (cytospin technique) for the diagnosis of intraocular lymphoma. Br J Ophthalmol 2006; 90(6): 690-2.

9. Fisson

S, Ouakrim H, Touitou V, Baudet S, Ben Abdelwahed R, et al. Cytokine profile in human eyes: contribution of new cytokine combination for differential diagnosis between intraocular lymphoma or uveitis. PLoS One 2013; 8(2): e52385.

10. Fox

CR Phillips EH, Smith J, Linton K, Gallop-Evans E, Hemmaway C, Auer DR Fuller C, Davies AJ, McKay R Cwynarski K; British Society for Haematology. Guidelines for the diagnosis and management of primary central nervous system diffuse large B-cell lymphoma. Br J Haematol 2019: 184(3): 348-363.

11. Grimm

SA, McCannel CA, Omuro AM, Ferreri AJ, Blay JY, Neuwelt

EA,

Siegal T, Batchelor T, Jahnke K, Shenkier TN, Hall AJ, Graus E Herrlinger U, Schiff D, Raizer J, Rubenstein J, Laperriere N, Thiel E, Doolittle N, Iwamoto EM, Abrey LE. Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report. Neurology 2008; 71(17): 1355-60.

12. Hormigo

A, Abrey L, Heinemann MH, DeAngelis LM. Ocular presentation of primary central nervous system lymphoma: diagnosis and treatment. Br J Haematol 2004; 126(2): 202-8.

13. Méhes

G.

A primer központi

idegrendszeri lymphomák patológiája. Magyar Onkológia 2017; 61: 81-87.

14. Merle-Béral

H, Davi E Cassoux N, Baudet S, Colin C, Gourdet T, Bodaghi B, LeHoang R Biological

diagnosis of primary intraocular lymphoma. Br J Haematol 2004; 124(4): 469-73.

15. Missotten

T, Tielemans D, Bromberg JE,

van

Hagen PM, van Lochern

EG, van Dongen JJ, Baarsma GS, Langerak AW. Multicolor flowcytometric immunophenotyping is a valuable tool for detection of intraocular lymphoma. Ophthalmology 2013; 120(5): 991-6.

16. Omuro

A, Correa DD, DeAngelis LM, Moskowitz CH, Matasar MJ, Kaley TJ, Gavrilovic IT, Nolan C, Pentsova E, Grommes CC, Panageas KS, Baser RE, Faivre G, Abrey LE, Sauter CS.

R-MPV

followed by high-dose chemotherapy with TBC

and

autologous stem-cell transplant for newly diagnosed primary CNS lymphoma. Blood 2015; 125(9): 1403-10.

17. Rohrbach

JM, Zierhut

M.

(Intraocular (oculocerebral) non-Hodgkin lymphoma). Ophthalmologe

2001;

98(5): 495-505.

18. Sagoo

MS, Mehta H, Swampillai AJ, et al. Primary intraocular lymphoma. Surv Ophthalmol 2014; 59: 503-516.

19. Sen

HN, Bodaghi B, Hoang PL, Nussenblatt R. Primary intraocular lymphoma: diagnosis and differential diagnosis.Ocul Immunol Inflamm 2009; 17(3): 133-41.

20. Schabet

M.

Epidemiology of primary CNS lymphoma. J Neurooncol 1999; 43(3): 199-201.

21. Soussain

C, Choquet S, Fourme E, et al. Intensive chemotherapy with thiotepa, busulfan and cyclophosphamide and hematopoietic stem cell rescue in relapsed or refractory primary central nervous system lymphoma and intraocular lymphoma: a retrospective study of 79 cases. Haematologica 2012; 97: 1751-1756.

22. Sugita

S, Takase H, Sugamoto Y, Arai

A,

Miura 0, Mochizuki M. Diagnosis of intraocular lymphoma by polymerase chain reaction analysis and cytokine profiling of the vitreous fluid. Jpn J Ophthalmol 2009; 53(3): 209-14.

23. Swerdlow

SH,

Campo E, Harris NL, Jaffe ES,

Pileri

SA, Stein H, Thiele J. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th Edition, vol 2, 4th ed. Lyon:

IARC

press; 2017.

Levelezési cím

Jr. Géhl

Zsuzsanna, 1085

Budapest, Üllői

út 28.

2-mail: zsuzsannagehl@gmail.com

vagy

gehl.zsuzsanna@med.semmelweis-univ.hu

1'176;