202921. lajstromszámú szabadalom • Eljárás humán tumor nekrózis faktort kódoló DNS, továbbá annak alkalmazásával a fenti faktornak megfelelő polipeptid, és hatóanyagként egy fenti polipeptidet tartalmazó gyógyszerkészítmények előállítására
1 HU 202 921 B 2 Ala Val Ser Tyr Pro Asn Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys His Arg Glu Thr Pro Glu Glu Ala Glu Pro Met Ala Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gin Leu Glu Lys Gly Asp Arg Leu Ser Thr Glu Val Asn Gin Pro Glu Tyr Leu Asp Leu Ala Glu Ser Gly Gin Val Tyr Phe Gly Ile Ile Ala Leu táblázat: (2-1) képlett! DNS-szekvencia (5> AGC ACT GAG AGT ATG ATC CGG GAC GTC GAG CTG GCG GAG GGG CCG CTC CCC AAG AAG GCA GGG GGG CCC CAG GGC TCC AAG CGC TGC CTC TGC CTC AGC CTC TTC TCT TTC CTG CTC GTG GCT GGA GCC ACC ACG CTC ITC TGC CTG CTG CAC TTC AGG GTG ATC GGC CCT CAG CAG GAA GAG CAG TCC CCA AAC AAC CTC CAT CTA GTC AAC CCT GTG GCC CAG ATG GTC ACC CTC AGA TCA GCT TCT CGG GCC CTG AGT GAC AAG CCT CTA GCC CAG GTA GTA GCA AAC CCG CAA GTG GAG GGC CAG CTC CAG TGG CTG AGC CAG CGT GCG AAC GCC CTG CTG GCC AAC GGC ATG AAG CTC ACG GAC AAC CAG CTG GTG GTG CCG GCC GAC GGG CTG TAC CTC ATC TAC TCC CAG GTT CTC TTC AGC GGT CAA GGC TGC CGC TCC TAC GTG CTC CTC ACT CAC ACT GTC AGC CGC TTC GCC GTC TCC TAC CCG AAC AAG GTC AAC CTC CTC TCT GCC ATC AAG AGC CCC TGC CAC CGG GAC ACC CCC GAG GAG GCT GAG CCC ATG GCC TGG TAC GAG CCC ATC TAC CTG GGC GGC GTC TTC CAG TTG GAG AAG GGT GAC CGG CTC AGC ACC GAG GTC AAC CAG CCT GAG TAC CTG GAC CTT GCC GAG TCC GGG CAG GTC TAC TTT GGG ATC ATT GCC CTG-(3’) táblázat: (2-2) képlett! polipeptid Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Gly Pro Leu Pro Lys Lys Ala Gly Gly Pro Gin Gly Ser Lys Arg Cys Leu Cys Leu Ser Leu Phe Ser Phe Leu Leu Val Ala Gly Ala Thr Thr Leu Phe Cys Leu Leu His Phe Arg Val Ile Gly Pro Gin Glu Glu Glu Gin Ser Pro Asn Asn Leu His Leu Val Asn Pro Val Ala Gin Met Val Thr Leu Arg Ser Ala Ser Arg Ala Leu Ser Asp Lys Pro Leu Ala His Val Val Ala Asn Pro Gin Val Glu Gly Gin Leu Gin Trp Leu Ser Gin Arg Ala Asn Ala Leu Leu Ala Asn Gly Met Lys Leu Thr Asp Asn Gin Leu Val Val Pro Ala Asp Gly Leu Tyr Leu Ile Tyr Ser Gin Val Leu Phe Ser Gly Gin Gly Cys Arg Ser Tyr Val Leu Leu Thr His Thr Val Ser Arg Phe Ala Val Ser Tyr Pro Asn Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys His Arg Glu Thr Pro Glu Glu Ala Glu Pro Met Ala Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe Gin Leu Glu Lys Gly Asp Arg Leu Ser Thr Glu Val Asn Gin Pro Glu Tyr Leu Asp Leu Ala Glu Ser Gly Gin Val Tyr Phe Gly Ile Ile Ala Leu 4
