200795. lajstromszámú szabadalom • Eljárás többszörös horgokat tartalmazó plazminogén aktivátorok előállítására
HU 200795 B Int Cl5 C 12 N 15/58 A 61 K 37/54 C példa (folytatás) 901 911 921 931 941 951 CTCCGAGGGCAACTCCGACTGCTATGAGGGGAATGGTCACTTTTACCGAGGAAAGGCCAG SerGluGlyAsnSerAspCysTyrGluGlyAsnGlyHisPheTyrArgGlyLysAlaSer —.....J 50 961 971 981 991 1001 1011 CACTGACACCATGGGCCGGCCCTGCCTGCCCTGGAACTCTGCCACTGTCCTTCAGCAAAC ThrAsDThrMetGlyArgProCvsLeuPrgTrpAsnSerAlaThrValLeuGlnGlnThr 1021 1031 1041 1051 1061 1071 GTACCATGCCCACAGATCTGATGCTCTTCAGCTGGGCCTGGGGAAACATAATTACTGCAG TyrHisAlaHisArgSerAspAlaLeuGlnLeuGlyLeuGlyLy5HisAsnTyrCysArq 1081 1091 1101 1111 1121 1131 GAACCCAGACAACCGGAGGCGACCCTGGTGCTATGTGCAGGTGGGCC1AAAGCCGCTTGT AsnProAspAsnArgArgArgProTrpCvsTyrValGlnValGlyLeuLysProLeuVal 1141 1151 1161 1171 1181 1191 CCAAGAGTGCATGGTGCATGACTGCTCCACCTGCGGCCTGAGACAGTACAGCCAGCCTCA GlnGIuCysMetValHisAspCysSerThrCysGlyLeuArgGlnTyrSerGlnProGln 131 262 1201 1211 1221 1231 1241 1251 GTTTCGCATCAAAGGAGGGCTCTTCGCCGACATCGCCTCCCACCCCTGGCAGGCTGCCAT PheArglleLysGlyGlyLeuPheAlaAspIleAlaSerHisProTrpGlnAlaAlalle 1261 1271 1281 1291 1301 1311 CTTTGCCAAGCACAGGAGGTCGCCCGGAGAGCGGTTCCTGTGCGGGGGCATACTCATCAG PheAlaLysHisArgArgSerPrcGlyGluArgPheLeuCysGlyGlylleLeuIleSer 1321 1331 1341 1351 1361 1371 CTCCTGCTGGATTCTCTCTGCCGCCCACTGCTTCCAGGAGAGGTTTCCGCCCCACCACCT SerCysTrpIleLeuSerAlaAlaHisCysPheGInGluArgPheProProHisHisLeu 1381 1391 1401 1411 1421 1431 GACGGTGATCTTGGGCAGAACATACCGGGTGGTCCCTGGCGAGGAGGAGCAGAAATTTGA ThrValIleLeuGlyArgThrTyrArgValValProGlyGluGluGluGlnlysPheGlu 1441 1451 1461 1471 1481 1491 AGTCGAAAAATACATTGTCCATAAGGAATTCGATGATGACACTTACGACAATGACATTGC ValGluLysTyrlleValHisLysGluPheAspAspAspThrTyrAspAsnAspIleAla 1501 1511 1521 1531 1541 1551 GCTGCTGCAGCTGAAATCGGATTCGTCCCGCTGTGCCCAGGAGAGCAGCGTGGTCCGCAC LeuLeuGlnleulysSerAspSerSerArgCysAlaGlnGluSerSerValValArgThr 1561 1571 15B1 1591 1601 1611 TGTGTGCCTTCCCCCGGCGGACCTGCAGCTGCCGGACTGGACGGAGTGTGAGCTCTCCGG ValCysLeuProProAlaAspLeuGlnLeuProAspTrpThrGluCysGluLeuSerGly 1621 1631 1641 1651 1661 1671 CTACGGCAAGCATGAGGCCTTGTCTCCTTTCTATTCGGAGCGGCTGAAGGAGGCTCATGT TyrGlyLysHisGluAlaLeuSsrProPheTyrSerGluArgLeuLysGluAlaHisVal 1681 1691 1701 1711 1721 1731 CAGACTGTACCCATCCACCCGCTGCACATCACAACATTTACTTAACAGAACAGTCACCGA ArgLeuTyrProSerSerArgCysThrSerGlnHisLeuLeuAsnArgThrValThrAsp 1741 1751 1761 1771 1781 1791 CAACATGCTGTGTGCTGGAGACACTCGGAGCGGCGGGCCCCAGGCAAACTTGCACGACGC AsrMetleuCysAlaGlyAspThrArgSerGlyGlyProGlnAlaAsnLeuHisAspAla 1801 1811 1821 1831 1841 1851 CTGCCAGGGCGATTCGGGAGGCCCCCTGGTGTGTCTGAACGATGGCCGCATGACTTTGGT CysGlnGlyAspSerGlyGlyProLeuValCysleuAsnAspGlyArcHetThrleuVal 1861 1871 1881 1891 1901 1911 GGGCATCATCAGCTGGGGCCTGGGCTGTGGACAGAAGGATGTCGCGGGTGTGTACACAAA GlyllelleSerTrpGlyLeuGlyCysGlyGlnLysAspValPrgGlyValTyrThrLys 1921 1931 1941 1951 1961 1971 GGTTACCAACTACCTAGACTGGATICGTGACAACATGCGACCGTGACCAGGAACACCCGA ValThrAsnlyrLeuAspTrpIleArgAspAsnMetArgProTEP 1981 1991 2001 CTCCTCAAAAGCAAATGAGATCCGGATCC ll.a ábra hexapeptid kapcsoló UK horog a.a. 50-131
