199803. lajstromszámú szabadalom • Eljárás 1-acil-2,3-dihidro-4(1H)-kinolin-4-oxim-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására

1

HU 199803 B

2

Pl.

R5 R6

IR(KBr,

NMR (CDCI3,

Op.

sz.

cm'1)

ppm)

CQ

(2H,t),7,04(lH,

s),7,82(lH,s)

26-och3 -och3

3350,1660

2,64(2H,t)3,55

105,1-1265,1170

(2H,dt),3,82(3H,

s),3,86(3H,s),

4,30(lH,m),6,12

(1H,s),7,29(1H,s)

108,9

9. Táblázat

(V) általános képletű vegyületek

Pl.

R1

IRlKBr.cm'1)

NMR (CDCI3, ppm)

Op.

SZ.

fC)

27-och3

1730,1695,

2,77(2H,t),3,88(3H,s),

106,7-1490,1225

4,20(2H,t),

7,39-8,00(3H,m)

107,1

28-ch3

1700,1670,

2,33(3H,s),2,79(2H,t),

149,2-1480,1200

4,20(2H,t)

7,47-7,98(3H,m)

150,2

29-CH2CH3

1700,1670,

1,23(3H,t),2,58(2H,q),

105,5-1480,1185

2,7 6(2H,t),4,18(2H,t), 7,45-7,98(3H,m)

106,4

30-(CH2)3CH3

1680,1470,

0,91(3H, t),l,13-l, 86

71,3-1380,1180

(4H,m),2,54(2H,t),2,75

(2H,t),4,14(2H,t),

7,38-7,91(3H,m)

74,2

31-(CH2)7CH3

1690,1670,

0,87(3H,t),l,07-2,24

(Olaj)

1460,1170

(12H,m),2,57(2H,t),

2,78(2H,t),4,20(2H,t),

7,48-8,00(3H,m)

32-CH2CH(CH3)2

1700,1655,

0,98(6H,d),2,18(1 H,m),

65,3-1485,1185

2,46(2H,d),2,78(2H,t), 4,21 (2H,t),7,44-8,02 (3H,m)

74,5

33-C(CH3)3

1695,1650,

l,41(9H,s),2,73(2H,t),

163,1-34

1470,1160

4,15(2H,t),

7,16-7,88(3H,m)

164,3-ch2ch2ci

1700,1670,

2,80(2H,t),3,04(2H,t),

107,0-1390,1190

3,88(2H,t),4,23(2H,t),

7,42-7,99(3H,m)

117,1

35-C(CH3)2CH2C1

1700,1660,

1,49(6H,s),2,78(2H,t),

148,0-1475,1150

3,71 (2H,s),4,15(2H,t), 7,37-7,92(3H,m)

150,9

36-CH2CH2C02CH3

1740,1655,

2,72(2H,t),2,75(2H,t),

107,8-1480,1170

2,79(2H,t),3,66(3H,s), 4,19(2H,t),7,18-7,93 (3H,m)

108,4

37-CH20CH3

1690,1475,

2,81(2H,t),3,47(3H,s),

96,5--<

1305,1200

4,18(2H,t),4,27(2H,s), 7,41-8,02(3H,m)

97,5

38

1700,1660,

0,78-1,33(4H,m), 1,80-146,7-1490,1180

2,1 l(lH,m),2,77(2H,t), 4,24(2H,t),7,17-7,95 (3H,m)

148,9

39

1700,1680

1,00-1,96(1 lH,m),2,73

92,7-1470,1190

(2H,t),4,15(2H,t),

7,38-7,96(3H,m)

94,0

40-c *0

1700,1680,

2,5 3(2 H,t) ,3,90(2 H,s),

102,7-1480,1195

4,08(2H,t),

104,9

10