195470. lajstromszámú szabadalom • Eljárás pszoriázis-ellenes hatású diaciloxi-naftalin-származékok és ezeket a vegyületeket tartalmazó gyógyszer készítmények előállítására

19

195 4'70

20

R3

W

R4

op. °C

R3

w

R4

op. °C

H-C2H5-ch3

111—112

6-C1-ch3

11-C3 h7

53-54

n-C3 H,-ch3

53-54-c

2hs

n-C3 H7

39-40

i-C3H7-ch3

95-96

n-C3H7

n-C3H7

28-29

t-C4 H9-ch3

178-180-ch

3

i-C3 H7

132-133

5-Cl-ch3-ch3

133-134-c

2hs

i-C3H7

58-59

t-C4 H9-ch3

128-130

n-C3 H-i-C.3 H7

olaj

J

i-C3H7

i-C3 H7

olaj

6-F-ch3-ch3

102-103

t-C4 H9

i-C3H7

olaj

6-Br-ch3-CH3

102-103

6-OCH3-ch3-CH3

77-78

6-C1-ch3-ch3

93-94

5-CH3-ch3-ch3

114-115-c

2h5-ch3

84-85-C2H

s-ch3

n-C3 h7-ch3

olaj

i-C3 H7-ch3

i-C3H7-ch3

64-65

t”C4 Hg-ch3

t-C4 Hg

-ch3

132-133-CH3-C2 h5

91-92

, 6-CH3-ch3-ch3

70-71-C2H

s-ch3

57-58

6—Cl-C2H5

•c2hs

81-82

i-c3h7-ch3

olaj

i-C3 H7-c2h5

77-78

t-C4 Hg-ch3

110-111

6-C1

t-C4 h9-Ci Hs

104-105

i-CjH,

n-C3H7

51-52

>s-c6h5-ch3-ch3

138-140

t-C4 h9

n-C3H7

59-60-ch

3

n-C4 H9

74-75

5-CH3O-ch3-ch3

69-70-c

2h5-ch3

72-73

Í-C4 H9-ch3

153-154

6-CH3O-Ci Hs-ch3

86-87

t-C4 Hg

■ch3

amorf

5-CN-ch3-ch3

152-153

6-CN-ch3-ch3

124-125

R”

X

Y

Ödéma-gátlás, %-coch3-ch3

Cl

H

51-coch2 ch3-ch3

Cl

H

49-COCH(CH3)2-ch3

Cl

H

23-coch3-ch2 ch3

Cl

H

38-coch2ch3-ch2ch3

Cl

H

50-COC(CH3)3-ch2ch3

Cl

H

19-COCH(CH3)2-ch2ch2ch3

Cl

H

28-coch3-ch2ch2ch3

Cl

H

23-coch3-ch3

H

H

19-coch2ch3-ch3

h

H

33-COCHj CH: CH2 CH3-ch3

H

H

59-COCH(CH3)2-ch3

H

H

53-coch3-ch3

F

H

40-coch3-ch3

Br

H

42-COCHj CH3-ch3-OCH3

H

49-coch3-ch3

H-oc:h3

47-COCHj CH3-ch3

H-och3

57-coch3-ch3

H-ex

24

10