195211. lajstromszámú szabadalom • Eljárás 5-alkil-1-fenil- 2-(piperazino-alkil)-pirazolin-3-on-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására

195211

22

21

IV. táblázat (folyt.)

A vegyület Rg Z R<, sé Op. °C

példa száma

19

ch3-2,5-di-ci

n-C3H6-4-CH3-2-pyr

2,5HC1

13 U

20

ch3-4-CH3 2-•Cl

n-C3H6-4“CH3 0-phen

Ba

110-112

21

Cll3-2-CH3 0

H

n-C3H6-4-CH3-2-pyr

3HC1

165-170

22

n—C 3H7

3,4-di-Cl

n-C3H6-4-F-phen

HC1

175-180

23

c2h5-4-C1

H

n-C3H6-4-CH3-2-pyr

3HC1

200-205

24

ch3-H

H

n-C3H6-6-CHj O-2-pyr

2HC1

162

25

ch3-H

H

n-C3H6-5-N02-2-pyr

Ba

140

26

n-C6H13-H

H

n-C3H6-4-CH3-2—pyr

3HC1

1 76

27

Cyclohex-H

H

n-C3H6-4-Cl-phen

2HC1

150

28

ch3-H

H

n-C3Hg-4-CH3CO-phen

Fu

136

29

ch3-4-N02

H

n-C3He-2-pyr

3HC1

139-145

30

CHj-4-C2HsO

H

n-C3H6-3-Cl-6-CH3-phen

Ba

119

31

(CH3)2-CH-CH2-H

H

n-C3H6-2-F-phen

2HC1

130-135

32

ch3-H

H

n-C3H6-5-CH3-2-pyr

Ba

115

33

ch3-H

H

ch2-ch-ch2-c\l2

4-CH3-2-pyr

3HC1

164-168

34

ch3-3-Br

H

n-C3H6

4-CH3-2-pyr

3,6HC1

168

35

ch3-4-CH3OCO

H

n-C3H6

4-F-phen

HCl

157-163

36

ch3-ch2-ch-H

H

n-C3H6

5-Cl-2-pyr

2.7HC1

160

37

CHj

H

H

n-C3H6

4-CH3-2-pyr

3HC1

184

38

c2h5-4-NO 2

H

n-C3H6

4-CH3-2-pyr

Ba

113

39

ch3 -4-N02

H

n-CjHe

4-F-phen

2HC1

Ba

175-180 70-71

40

ch3-2-F

H

ch2-ch2-cn c!h3

3-Cl-phen

Ba

01

41

c2 H5-3-CF3

H

CH2 -C|I-CH2

4-CH3-2-pyr

Ba

01

42

ch3-2-F

H

ch-ch2-ch2 ch3

3-Cl-phen

Ba

01

43

Cycloprop-H

H

n-C3 H6

4-F-phen

Ba

1 27-128

44

ch3-4-CH3C0

H

n-C3H6

4-CH3 - 2-pyr

3HC1

210

45

ch3-H

H

n-C3H6

2-pyr

3HC1.1H20

130

46

ch3-4-CN

H

H'-Cj h6

4-CH3-2-pyr

2,4 HCl

205-210

4 7

ch3-4-Cll3 0

H

n-C3H6

4-CH3-2-pyr

2,6 HCl

20U-205

48

ch3-4-CH3 0C0

H

n-C3 Hß

4-CH3-2-pyr

HCl,0,5H20

115-120

49

Cyclohex-H

H

n-C3H6

4-F-phen

2,4HC1

165-170

50

c2h5-H

H

ch2-cn-ch2

CH 3

4-F-phen

Ba

129-130

51

Cyclohex-H

H

ch2-ch-ch2

CHí

4-CH3-2-pyr

Ba

85-90

52

ch3-H

H

n—CtjHg

2,6-di-CHa-phen

2HC1

182

53

ch3-4-CO0C2H5

H

n-C3He

4-CH3-2-pyr

HC1.0,5H20

169-170

54

c2h5-4-NO 2

H

n-C3H6

4-F-phen

1,2 HCl

185-190

55

ch3-4-CH3

H

n-C3H6

4-CH3-2-pyr

1,1 HCl

190-195

56

ch3-3,4-di-OCH3

n-GaH6

4-CH3-2-pyr

2,6HC1.0,3H20

205-210

57

CHj-3,4-0-CH2-CH

2-0

n-C3115

4-CH3-2-pyr

1,6HC1.0,3H2ü

200-205

58

Cyclopent-H

H

n-C3H6

4-CH3-2-pyr

2,7 HCl

162-164

59

ch3-4-COCH3

H

n-C3H6

4-F-phen

Ba

107-110

60

ch3-4-CN

H

n-C3H„

4-F-phen

Ba

116-117

61

ch3-4-OCH3

H

n-C3H6

4-F-phen

Ba

132-133

62

ch3-4-C1

H

n-C3H6

4—F—phen

Ba

84-86

63

Cyclopent-H

H

n-C3Hb

4-F-phen

1,8 HCl

144-149

pyr = piridil; phen *= fenil; cyclohex = ciklohexí.1; cycloprop ** ciklopropil; cyclopent - ciklopentil; HC1 = hídroklorid; ol =* olajos; Ba = bázis; Fu - fumarát.

J3