190898. lajstromszámú szabadalom • Antidotumként 8-oxi-kinolin-származékokat tartalmazó készítmények, valamint eljárás a 8-oxi-kinolin-származékok előállítására

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190.898

18

Hatóanyag

sorszáma , R2 R, R4 Rs R6 X Y

110.

H

H

H

H

111.

H

H

H

H

112.

H

H

H

H

113.

H

H

H

H

114.

H

H

H

H

115.

H

H

H

H

116.

H

H

H

H

117.

H

H

H

H

118.

Br

H

Cl

H

119.

H

H

H

H

120.

H

H

H

H

121.

H

H

H

H

122.

H

H

H

H

123.

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H

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124.

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H

H

H

125.

H

H

H

H

126.

H

H

H

H

127.

H

H

H

H

128.

Br

H

Cl

H

129.

H

H

H

H

130.

H

H

H

H

131.

H

H

H

H

132.

H

H

H

H

133.

H

H

H

H

134.

H

H

H

H

135.

H

H

H

H

136.

H

H

H

H

137.

H

H

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H

138.

H

H

H

H

139.

H

H

H

H

140.

H

H

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H

141.

H

H

H

H

142.

H

H

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H

143.

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144.

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145.

H

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H

146.

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147.

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148.

H

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149.

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150.

H

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151.

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152.

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153.

H

H

H

H

154.

H

H

H

H

155.

H

H

H

H

156.

Br

H

Cl

H

157.

H

H

H

H

158.

H

H

H

H

159.

H

H

H

H

160.

H

H

H

H

161.

H

H

H

H

162.

Br

H

Cl

H

163.

H

H

H

H

164.

Br

H

Cl

H

165.

H

H

H

H

166.

H

H

H

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167.

H

H

H

H

168.

Br

H

Cl

H

169.

H

H

H

H

170.

H

H

H

H

171.

H

H

H

H

172.

Br

H

Cl

H

173.

H

H

H

H

174.

H

H

H

H

H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH,)~

H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-ch2--CH(CH3)H

H

H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CHj)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH,)H

H-ch2-H

H-CH(CH3)H

H-CH(CH,)H

H-CH(CH,)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH,)H

H-CH(CH,)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3>H

H-CH(CH3)H

H-CH(CH3)H

H

CH(CH3)H

H-CH(CH3)H

H-CH(CH,)H

H-CH(CHj)H

H-CH(CH3)H

H

CH(CH3>H

H

CH(CH3)H

H

ch2ch2-H

H

CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH,)H

H-CH(CH3)H

H-ch2ch2-H

H- CH(CHj)H

H-ch2ch2-H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-CH2CH,H

H-CH(CH3)H

H-CH(CH3)H

H-CH(CH3)H

H-ch2ch2-H

H-CH(CH3)H

H-CH(CH,)(mm)

(nn)

-COOCH2C(CH3)

hch2ch2ch3

(oo)-COO(Ch2),Cl-CONH(CH,)3Cl-C00CH2-CH(N02)-CH,

(pp)-CON(CH,)j-cooch2-ch=ch-ch3 (rr)

(ss)

(tt)-COO(CH2)10OH-COO(CH,)9CH3-CONH(CH2)„CH3-CON(CH2CH2OH)2-CON(C2H5)2-conh2-COOCH2CH2N(C2H5)2-CONHCH2CH2N(C2Hs)2-COOCH2CH2OCI IX'H,

OC2H5

(uu)-CONH(CH,)3-N(C2H5)2-COOCH2CH2ÖCH2CH2OC4H9n-COOCH2CH2OCH2CH2OCH3-cooch2ch,och2ch2oh-CON(CH2CH=CH,)2

(vv)-CONH(CH2)„NH2-COOCH2CH(Br)-CH2Br-CON(C4H9n)2

(xx)-CONH(CH2)8NH,-cooch2ch,

N(CH2CH2CH2CH3)2-CONHCH2CH,N(C4H9n),-CONH(CH2)3NH2

(yy)-COO(CH2),7CH3-COOCH(CH2Cl)2

(zz)

(aaa)-cooch2ch2no2

(bbb)

(ccc)-CON(CH3)2-cooch3-COOCH2CH2N(CH3)2

(ddd)

(eee)-COOCH(CH3)CH2N(CH,)2-COO(CH2)3N(CH3)2-COOCH,-CONH(CH2)3N(CH3)2-cooc2h5

(fff)

(gee)-CON(C5H,,n)2-COOC3H7n

(hhh)-CON(C3H7n)2-COCKCH^CH,-CONH2-CONH(CH2)uCH3

(b)

Fizikai

állandó

op.: 120-121°C

op.: 105-111°C

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