190898. lajstromszámú szabadalom • Antidotumként 8-oxi-kinolin-származékokat tartalmazó készítmények, valamint eljárás a 8-oxi-kinolin-származékok előállítására

21

190.898

22

Hatóanyag

sorszáma

R

1

r2

R.

r4

R,

R„

X

Y

Fizikai

állandó

243.

Cl

H

Cl

H

H

H-CH(CH,)-CONH,

244.

H

H

j

H

H

H-CH(CH,)-COOCH,

245.

H

H

Br

H

H

ch,-CH(CH,)-COOCH,

246.

H

H

J

H

H

H-CH(CH,)-COOC,H,

247.

H

H

J

H

H

H-CH(CH,)-CONHCH,

248.

H

H

Br

H

H

ch3-CH(CH,)-CON(CH3)j

249.

H

H

Br

H

H

H-CH(CH3)-COOH

250.

H

H

Br

H

H

H-CH(CH3)-cooch2ch2och3

251.

H

H

J

H

H

H-CH(CH,)-CON(CH3)j

252.

H

H

Br

H

H

H-CH(CH,)-COOCH,

253.

H

H

Cl

H

H

ch3-CH,-COOCH,

254.

H

H

Br

H

H

H-CH(CH,)-CONHj

255.

H

H

Cl

H

H

CHj-ch2--COOCjH,

256.

H

H

Br

H

H

H-CH(CH3)-CONHCH,

257.

H

H

Cl

H

H

ch,-ch2--CONHCH,

258.

H

H

H

H

H

H-ch2ch2--COOH

259.

H

H

Cl

H

H

H-ch2ch2--COOCjH,

260.

H

H

Cl

H

H

ch3-CHj-CON(CH,)j

261.

H

H

H

H

H

H-ch2ch2--COOCHjCHjOCH,

262.

H

H

Cl

H

H

H-ch2ch2--COOC,H7izo

263.

H

H

Cl

H

H

CH,-CH(CH3)-COOH

264.

H

H

H

H

H

H-ch2ch2--COOCH,

265.

H

H

Cl

H

H

CH,-CH(CH3)-COOCH,

266.

H

H

H

H

H

H-CH2CH2--COOCjH,

267.

H

H

Cl

H

H

CH,-ÇHCH,-CH2CHr-COOCjH,

268.

H

H

H

H

H

H-COOC3H7n

269.

H

H

Cl

H

H

ch3-CH(CH3)-COOC3H7izo

270.

H

H

H

H

H

H-ch2ch2--CONHC,H7ízo

271.

H

H

Cl

H

H

ch3-CH(CH3)-CONHCH,

272.

H

H

Cl

H

H

H-ch2ch2--CONHCH,

273.

H

H

Cl

H

H

ch3-CH(CH3)-CON(CH,)j

274.

H

H

H

H

H

H-ch,ch2--CON(CH,),

275.

H

H

Cl

H

H

H-ch,ch2--CON(CH3)j

276.

H

H

Cl

H

H

H-CHjCHj-CONHCH,

277.

H

H

H

H

H

H-ch2ch2--CONHCjH,

278.

H

H

Cl

H

H

H-ch2ch2--CONH,

279.

H

H

H

H

H

H-ch2ch2--CON(C2H,)j

280.

H

H

Cl

H

H

H-CH(CHj)-COOH

281.

H

H

H

H

H

H-ch2ch2--CONH,

282.

H

H

Cl

H

H

H-CH(CH3)--COOCHjCHjOCH,

283.

H

H

H

H

H

H-ch2ch2--COOCHjCHjOCjH,

284.

H

H

Cl

H

H

H-CH(CH,)-COOCH,

285.

H

H

H

H

H

H-CHjCHj(z)

286.

H

H

Cl

H

H

H-CH(CHj)-COOCjH,

287.

H

H

Cl

H

H

H-CHj-COOH

op.: 232-233 °C

288.

H

H

Cl

H

H

H-CH(CHj)-COOC3H7n

289.

H

H

Cl

H

H

H-ch2--COOCH2CHjOCH3

op.: 97-98 °C

290.

H

H

Cl

H

H

H-CH(CH,)-CONHCH,

291.

H

H

Cl

H

H

H-CH-COOCH,

op.: 104-105,5 °C

292.

H

H

H

Cl

H

H-CH(CH3)-CON(CH,)j

293.

H

H

Cl

H

H

H-CHj-COOCjH,

op.: 116-117 °C

294.

H

H

Cl

H

H

H-CH(CH3)-CONHCjH,

295.

H

H

Cl

H

H

H-CHj-COOC,H7n-CON(C2H,)j

op.: 108-109°C

296.

H

H

Cl

H

H

H-CH(CH3)-297.

H

H

Cl

H

H

H-CHj-CONHCH,

298.

H

H

Cl

H

H

H-CH(CH,)-CONH,

299.

H

H

Cl

H

H

H-CH,-CON(CH,)j

op.: 135-136 °C

300.

H

H

Cl

H

H

H-CH~(CH,)-COOCH, CHjOCjH,

301.

H

H

Cl

H

H

H-CH-CONH,

302.

H

H

Cl

H

H

H-CH(CH,)-conh(ch2),ch3

303.

H

H

Cl

H

H

H-CH.CHj-COOH

304.

H

H

Cl

H

H

H-CH CH,--COOCHjCHjOCH,

305.

H

H

Cl

H

H

H-CH CHj-COOCH,

306.

H

H

Cl

H

H

H-CHiCH,)(z)

307.

H

H

H

H

H

ch3-CH --COOCH,

op.: 58-66°C

308.

H

H

H

H

H

CH,-CH(CHj)COOH

309.

H

H

Cl

H

H

H-CH(CHj)(b)

12