184680. lajstromszámú szabadalom • Eljárás az oldalláncban amino-tiazolil csoportot tartalmazó cef-3-ém-4-karbonsav-származékok előállítására

184 680

R,

r2

r3

R-4

X

A-H-H

(422)-H

—S—-ch2-o-c-ch3

O-H-H

—H

OCH,-S-CH2-0-C-CH3

0-H

(428)-H-H-s-ch2-o-c-ch3

O-H

(429)-H-H-s-ch2-o-c-ch3

0-H

-chch2-so3h-H-H-s-ch2-o-c-ch3

0-H-ch2-so2nh2-H-H-s-ch2-o-c-ch3

II

0-H

(428)-H-H

—s-CH2-0-C-CH3

II

0-H

(428)-H-H-s-ch2-s-c-ch3

II

O-H-CH2-COOC2Hs-H

och3

-s-ch2-o-c-nh2

O

N3-CH2-CII

O-ch3-H-H-s-ch2-o-c-ch3

II

O

(430)-ch3-H

—H-s(264)

ncs-ch2—c— II

O-ch3

—H

—H

—s—-ch2-s-c— ch3

U

0

(431)-ch3-H-H-s(377)-H-ch3-CH-O-C

1 «

CH3 0-OC2H5-H-s(2)-H-ch3

(422)-H-s(377)-H-ch3

(422)-H-s(264)-H-H

(422)

—H-s(377)

O

II

—H-H

(422)-H-s-ch2-s-c-ch3

—H-H

(422)

—H-s(264)-H-H

(422)

—H-s-ch2-o-c-ch3

II

0

(432)-CH,-H-H-s-ch2-o-c-ch3

II

O

(433)

(422)-H-H-s-ch2-o-c-ch3

1

O

(434)-ch3

(422)-H-s(264)

(431)-ch3

(422)

ch3-H-s-X

U

1

u=o

1

0 1

X

O

1

(431)-ch3-ch2-o-c-H

O

1

C-CH3

1

ch3-H-s-ch2-o-c-ch3

n

o

(431)-CH3-ch2-cooh-H-s-ch2-o-c— ch3 «

O

(435)-ch3-H-H

—s—-ch2-o-c-ch3

n

O

(436)-ch3-H-H

—s-ch2-o-c-ch3

O

(437)-ch3

—H-H-s-ch2-o-c-ch3

II

0

(438)-ch3-H

—H-s-ch2-o-c-ch3

I

o

19