182965. lajstromszámú szabadalom • Eljárás új n-heterociklil-piperidin-4-amin-származékok és savaddíciós sóik előállítására

182 965

L—N

L

R

R1

R

(R3)n

Q

Bázis vagy só forma

Olvadáspont

C„ H, -(CHj), -H

H-ch3

H

=CH—

2HC1. 1|2HjO

298,3 °C

C„ H, -(CHj )2 -H

H-CjH5

H

=CH—

bázis

192,8 °C

C6H;-(CH:)2-H

H

nC3 H, -H

=CH—

2HCl. l/2HjO

278,8 °C

C6Hs-(CH3)2-H

H

C.Hj-CHj-H

=CH-bázis

141,9 °C

C6H,-(CH!)j-H

H

nC5HM

H

=CH-2HCl.Hj 0

243,5 °C

C6 Hÿ—.(CHj)j -H

H

nC,H15

H

=CH—

2HCl.Hj 0

212,8 °C

C6 Hf -(CHj )j —

H

H

nC4 H,

H

=CH-2HC1. l/2HjO

274,4 °C

C„ H, -(CHj )2 —

H

H

nC6H13

H

=CH—

2HCl.HjÔ

224,2°C

C6H5-(CH; )2-H

H

H

=CH—

2HC1. l/2HjO

285,6 °C

C6 Hj -(CH; )j -H

H

iC3 H7 -H

=CH—

2HC1

295,8 °C

C6H5-(CHj),H-CH3

H

H

=CH-2HC1

299,6 °C

C, H. iCIFCH

H

2-C1-C

h4 --CHj-H

=CH—

2HC1. l/2Hj 0

244,4 °C

C6H5-(CH,)j-H

H

4-Br-C

6H4--CHj -H

=CH—

2HCl.HjO

251,5 °C

C6 Hs -(CH; )j -H

H

4-CHjc,h4--CHj -H

=CH-2HCl.HjO

191,4 °C

Cfi Hj -('CHj )2 —

H

H

4-F-C.

h4--CHj-H

—CH-2HC1

281,1 °C

C6H,-(CHj)2-H

nC4H,H

H

=CH-bázis

183,4°C

C6Hs- ICH2)2-H

H

2-F-C,

h4--CHj

-H

=CH—

bázis

138,6 °C

C„H5-(CH,),H

H

H

H

=CH-bázis

192,1 °C

<\ H . - iCH. 1.

H

H

C6 H5 -CHj -5-CF j—

=CH-2HC1

264,7 °C

C6 H,—(CH, >, -H

H

4-F-C.

h4--CHj-5-Cl

=CH-bázis

168,3 °C

C6 H, -(CH2 )2 -H

H

4-F-C6

h4--CHj

-5(6)-CH3-=CH-bázis

203-215 °C

C6 Hs-(CH2 )2 -H

H

C6Hs-CH,-5(6)-CH3-=CH-bázis

181,9 °C

C6Hs-(CH2;2-H

H

C6 H5 -CHj-5(6)- F

=CH—

bázis l/2Hj 0

146,1 "C

C6 Hs — (CHj )2 -H

H

4-r-c„

h4--CHj-H

=N-bázis

193,2 °C

C6 H5 -(CHj )2 —-CH3

H

C6 Hj -CHj -H

=CH-2HCl.Hj 0

297,9°C

(cisz+transz-izomer)

C6Hs-(CH2)2--ch3

H

4-F-C6

H.,H

=CH—

2HCl.Hj 0

220,3 °C-CHj

(cisz + transz-izomer)

4--N02 -C6 H„ —

H

H

4-F-C6

h4-H

CH

bázis

162,7 °C-(CHj )2 --CHj

C.. H. -(CH . 1.

H

H

C6 Hj -CHj -H

=CH—

2HCl.Hj O

197,1 °C

CHj =CH-CH2 —

H

H

CjHj-H

=CH—

2HN03. 1)2HjO

258,1 °C

CHj=CH-CH2-H

H

C6 Hj -CHj -H

=CH-2HCl.HjO

261,9 °C

C6H5-0-(CH3)3-H

H

C6H5-CHj-H

=CH—

2HC1. 1|2HjO

208,8 °C

Cb Hs -0-(CH2)3-H

H

4-F-C6

h4-—CHj -H

=CH-bázis

144,5 °C

C6H5-0-(CHj)3-H

H

4-F-C,

H4 -—CHj —

H

=N—

bázis

157,6 °C

C6Hs-0-(CHj)3--ch3

H

4-F-C,

h4 —-CHj

H

=CH—

2(COOH)j Hj 0

141,3 °C

(C6H5)jCH-(CHj

)j-H

H

C6 Hj—CHj -H

=CH-bázis

173,8 “C

nC4H,~

H

H

C, H, -CHj —

H

=CH—

2HCl.HjO

273,3 °C

C6Hs-CO-CH2-H

H

C, Hj -CHj -H

=CH-2HN03. 3Hj 0

135,6 °C

(C6 Hs )2 CHH

H

C,H5-CHj-H

=CH-bázis

203,7'°C

C6Hs-CH(CH3)H

H

C, Hj -CHj -H

=CH-bázis

154,0 °C

QHs-CH(CH3)-CHj

H

H

C, Hs -CHj —

H

=CH—

2HN03 Hj 0

159,0 °C

C6H;-CH(CH3)H

H

4-F-C,

h4--CHj —

H

=CH—

bázis

170-172,8 °C

C6H5 ■''(('l'Hj )• •

H

H

4-F-C,

h4-H

=CH-2HN03 2Hj 0

155,4 °C-CHj-CHj-11